| Source: | Streptomyces griseusvar griseus |
| Synonyms | Ammonium Ionophore. Werramycin-A. Polynactin |
| Description: | Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin.
Nonactin batches released since May 2010 are better than 95% Nonactin by
NMR; detailed information is available on request |
| CAS number: | 6833-84-7 |
| Merck index: | 12: 6770 |
| Molecular weight: | 736.93 (for Nonactin) |
| Structure: | 
 |
| Molecular Formula: | C40H64O12 |
| Canonical SMILES: |
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Solubility
information: | Methanol, Dichloromethane, Ethyl Acetate, DMSO. Insoluble in water |
| Specifications | |
| Appearance: | White needle-like crystals. |
| Purity: | At least 99% by TLC of tetramacrolides, by TLC.
Current lot : less than 1%
Monactin, by NMR |
| λmax: | 205 |
| Melting point | 145ºC - 146ºC |
| Solubility | Clear colorless solution at 10mg/ml Dichloromethane
Clear colorless solution at 10mg/ml DMSO |
| Storage | -20oC, protect from moisture. Nonactin crystals may be hygroscopic. |
| Applications | Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea
and ammonium specific electrodes. |
| Classification | macrotetrolide
Ammonium ionophore |
| Warnings | Potentially toxic and eye irritant |
| Related products | Valinomycin |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Garcia CA, Junior LR, Neto Gde O.
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane.
J Pharm Biomed Anal. 2003 Feb 5;31(1):11-8. |
| | Korotkov SM, Glazunov VV, Yagodina OV.
J Biochem Mol Toxicol. 2007;21(2):81-91
Increase in the toxic effects of Tl+ on isolated rat liver mitochondria in the presence of nonactin. |
| |
Shlyonsky VG, Markin VS, Andreeva I, Pedersen SE, Simon SA, Benos DJ, Ismailov II.
Biochim Biophys Acta. 2006 Nov;1758(11):1723-31.
Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. |
| | JAMES E. HALL, RAMON LATORRE
Biophys J. 1976 Jan;16(1):99-103
NONACTIN-K+ COMPLEX AS A PROBE FOR MEMBRANE ASYMMETRY |
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