| Source: |
Fusarium sp. |
| Synonyms |
-
Trichothec-9-en-8-one,12,13-epoxy-3a,4b,7a,15-tetrahydroxy-(8CI);
-
12,13-Epoxy-3a,4b,7a,15-tetrahydroxytrichothec-9-en-8-one;
- 3a,4b,7a,15-Tetrahydroxyscrip-9-en-8-one;
- NSC 269143;
- Nivalenol
|
| Description: |
Nivalenol is a type - B trichothecene mycotoxin, produced by molds such as
Fusarium cerealis,
Fusarium graminearum. Nivalenol may be formed
by higher plants and by mamals, as a productt of biodegradation of other
thrichothecenes. |
| CAS number: | 23282-20-4 |
| Merck index: | |
| Molecular weight: |
312.3 |
| Structure: |
 |
| Molecular Formula: | C15H20O7 |
Solubility
information: |
Dichloromethane, DMSO, Methanol. Slightly soluble in water |
| Specifications | |
| Appearance: |
White crystalline powder |
| Purity: |
99% by TLC |
| λmax: | |
| Melting point |
127°C- 130°C |
| Solubility |
10 mg/ml of methanol gives a clear colorless
solution
10 mg/ml of DMSO gives a clear
colorless
solution |
| Storage |
-20°C. Protect from light.
Comment: trichocethenes are thermostable
compounds and are not destroyed in boiling. |
| Applications |
Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells
(Ueno et al., 1995).
Nivalenol was shown to inhibit protein synthesis in rabbit
reticulocytes in vitro.
Nivalenol inhibited the synthesis of nucleic acids in vitro (Ueno and Fukushima,
1968) |
| Classification | chemical class:
trichothecene mycotoxin
|
| Related products |
Fusarenon X; T2 toxin, HT2 toxin, Neosolaniol, Vomitoxin
|
| Warnings |
Very toxic - T+Toxity (rodents): LD50 PO
4-20 mg/Kg |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
7AAD by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| |
Effect of Nivalenol on IL-1beta and
TNF-alpha secretion
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Apr;26(4):313-215.
Cao PH, Cao JL, Cao LM, Yang YJ, Li WB. |
| |
Rapid deposition of glomerular IgA in BALB/c mice by nivalenol and its
modifying
effect on high IgA strain (HIGA) mice.
Exp Toxicol Pathol. 2009 Sep 26.
Dewa Y, Kemmochi S, Kawai M, Saegusa Y, Harada T, Shimamoto K, Mitsumori K,
Kumagai S, Sugita-Konishi Y, Shibutani M. |
|
 |
New product! announced at
June 2010 |
EUROPEAN COMMISSION
HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL
FUSARIUM TOXINS
PART 41: NIVALENOL
|
Trichothecenes on Wikipedia |
|
