| Source: | Streptomyces hygroscopicus |
| Synonyms | Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-46 |
| Description: | Nigericin: a polyether antibiotic and ionophore |
| CAS number: | 28643-80-3 |
| Merck index: | 12, 6633 |
| Molecular weight: | 747 |
| Structure: |
 |
| Molecular Formula: | C40H67O11Na |
Solubility
information: | Nigericin is soluble in Dichloromethane, Methanol, Ethanol, Ethyl Acetate. Nigericin is practically insoluble in water. |
| Specifications | |
| Appearance: | White powder |
| Purity: | At least 98% by TLC, HPLC |
| λmax: | |
| Melting point | 261°C-265°C (decomposition) |
| Solubility | Clear colorless solution at 10mg/ml Dichloromethane |
| Storage | -20°C |
| Applications | Nigericin was originally used as an antibiotic. Nigericin is active against gram positive bacteria.
Inhibitor of Golgi functions.
Exhibits anti-HIV activity. |
| Warnings | TOXIC |
| Classification | polyether
ionophore |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Nigericin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Kucejova B, Kucej M, Petrezselyova S, Abelovska L, Tomaska L.
A screen for nigericin resistant yeast mutants revealed genes controlling mitochondrial volume and mitochondrial cation homeostasis.
Genetics. 2005 Oct;171(2):517-26 |
| | Hamidinia SA, Tan B, Erdahl WL, Chapman CJ, Taylor RW, Pfeiffer DR.
The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin.
Biochemistry. 2004 Dec 21;43(50):15956-65. |
| | Chu CY, Kao YS, Fong JC.
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes.
J Cell Biochem. 2002;85(1):83-91. |
