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cancer research reagents

Myriocin

MSDSSample CoA
 
Source: Mycelia sterilia (fungus)
SynonymsThermozymocidin,
ISP-I
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Description: Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer
CAS number: 35891-70-4
Merck index: N.A.
Molecular weight: 401.54
Structure:

The molecular structure of myriocin. Free to copy

 

Molecular Formula: C21H39NO6
Canonical SMILES:  
Solubility
information:
Myriocin is slightly soluble in DMSO, alcohols.
Myriocin is insoluble in water and in most organic solvents.
Specifications 
Appearance: Off-white to grey powder.
Purity: At least 97% by TLC
λmax: 
Melting point175oC-180oC
Solubility 
Storage-18oC.
ApplicationsMyriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids.

Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.

Warnings 
Classificationamino-acid antibiotic
immunosupressor
serine palmitoyltransferase inhibitor
Related products 
 For Research use only. Not for Human or Drug use
GMP/API grade available on request

Myriocin by Fermentek is not produced from or contains any ingredients from animal origin.

No genetically modified organisms are used.
Publications 
 J. Biol. Chem., Vol. 280, Issue 11, 10284-10289, March 18, 2005
Effect of Myriocin on Plasma Sphingolipid Metabolism and Atherosclerosis in apoE-deficient Mice
Mohammad Reza Hojjati, Zhiqiang Li, Hongwen Zhou, Songshan Tang, Chongmin Huan, Everlyn Ooi, Shendi Lu, and Xian-Cheng Jiang
 J Antibiot (Tokyo). 1994 Feb;47(2):216-24.
Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Yoneta M, Chiba K, Hoshino Y, Okumoto T.


Mycelia sterilia is a thermophylic fungus that produces myriocin

Mycelia sterilia, producer of Myriocin 

 
Clinical perspectives

...myriocin induces growth inhibition of B16F10 melanoma cells...
( Lee YS in Cell Prolif. 2011 Jun 6. )


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myriocin by Fermentek for sale.