|Source: ||Mycelia sterilia (fungus)|
|Description: ||Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer|
|CAS number: ||35891-70-4 |
|Merck index: ||N.A.|
|Molecular weight: ||401.54|
|Molecular Formula: ||C21H39NO6|
|Myriocin is slightly soluble in DMSO, alcohols.|
Myriocin is insoluble in water and in most organic solvents.
|Appearance: ||Off-white to grey powder.|
|Purity: ||At least 97% by TLC|
|Applications||Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. |
Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.
serine palmitoyltransferase inhibitor
|Related products|| |
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
Myriocin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
| ||J. Biol. Chem., Vol. 280, Issue 11, 10284-10289, March 18, 2005|
Effect of Myriocin on Plasma Sphingolipid Metabolism and Atherosclerosis in apoE-deficient Mice
Mohammad Reza Hojjati, Zhiqiang Li, Hongwen Zhou, Songshan Tang, Chongmin Huan, Everlyn Ooi, Shendi Lu, and Xian-Cheng Jiang
| ||J Antibiot (Tokyo). 1994 Feb;47(2):216-24.|
Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Yoneta M, Chiba K, Hoshino Y, Okumoto T.
Mycelia sterilia, producer of Myriocin
...myriocin induces growth inhibition of B16F10 melanoma
( Lee YS in Cell Prolif. 2011 Jun 6. )