| Source: | Mycelia sterilia (fungus) |
| Synonyms | Thermozymocidin,
ISP-I
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid |
| Description: | Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer |
| CAS number: | 35891-70-4 |
| Merck index: | N.A. |
| Molecular weight: | 401.54 |
| Structure: | 
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| Molecular Formula: | C21H39NO6 |
| Canonical SMILES: |
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Solubility
information: | Myriocin is slightly soluble in DMSO, alcohols.
Myriocin is insoluble in water and in most organic solvents. |
| Specifications | |
| Appearance: | Off-white to grey powder. |
| Purity: | At least 97% by TLC |
| λmax: | |
| Melting point | 175oC-180oC |
| Solubility | |
| Storage | -18oC. |
| Applications | Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin. |
| Warnings | |
| Classification | amino-acid antibiotic
immunosupressor
serine palmitoyltransferase inhibitor |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Myriocin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | J. Biol. Chem., Vol. 280, Issue 11, 10284-10289, March 18, 2005
Effect of Myriocin on Plasma Sphingolipid Metabolism and Atherosclerosis in apoE-deficient Mice
Mohammad Reza Hojjati, Zhiqiang Li, Hongwen Zhou, Songshan Tang, Chongmin Huan, Everlyn Ooi, Shendi Lu, and Xian-Cheng Jiang |
| | J Antibiot (Tokyo). 1994 Feb;47(2):216-24.
Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Yoneta M, Chiba K, Hoshino Y, Okumoto T. |
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Mycelia sterilia, producer of Myriocin |
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Clinical perspectives
...myriocin induces growth inhibition of B16F10 melanoma
cells...
( Lee YS in Cell Prolif. 2011 Jun 6. )
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