| Source: |
Streptomyces conglobatus |
| Synonyms | |
| Description: | Ionomycin :
a Ca++ ionophore |
| CAS number: | 56092-82-1 |
| Merck index: | |
| Molecular weight: | 747.07 |
| Structure: | 
 |
| Molecular Formula: | C41H70O9Ca |
| Canonical SMILES: |
|
Solubility
information: |
DMSO, Ethanol, Methanol |
| Specifications | |
| Appearance: | White to pale
yellow crystalline solid. |
| Purity: | At least 98% by TLC, HPLC
current lot : 99.2% by HPLC |
| λmax: | |
| Melting point | 204°C-206°C |
| Solubility | Clear colorless
solution at 5 mg in 1 ml of DMSO |
| Storage | +4°C. Protect from light. |
| Applications |
Ionomycin is more effectivethan A23187 as a Ca++ionophore.
Ionomycin is used in research on Ca++ transport across biological membranes;
Ionomycin induces apoptotic degeneration of embryonic cortical neurons |
| Warnings | Potentially hazardous.. To our
knowledge, the hazards of this material have not yet been thoroughly
investigated. |
| Classification | Fatty acid antibiotic
Calcium Ionophore |
| Related products | Also available as
free acid |
| | For Research use only.
Not for Human or Drug use
GMP/API grade available on request
No
genetically modified organisms are used. |
| Publications | |
| |
Holmes AG, Watt MJ, Carey AL, Febbraio MA.
Ionomycin , but not physiologic doses of epinephrine, stimulates skeletal
muscle interleukin-6 mRNA expression and protein release.
Metabolism. 2004
Nov;53(11):1492-5. |
| |
McCollum AT, Jafarifar F, Chan R, Guttmann RP.
Oxidative stress inhibits ionomycin -mediated cell death
in cortical neurons.
J Neurosci Res. 2004 Apr
1;76(1):104-9. |
| |
Cavarra MS, Assef YA, Kotsias BA.
Effects of ionomycin and thapsigargin on ion currents in
oocytes of Bufo arenarum.
J Exp Zoolog A Comp Exp Biol. 2003 Jun 1;297(2):130-7. |
| |
Abramov AY, Duchen MR.
Actions of ionomycin, 4-BrA23187 and a novel
electrogenic Ca2+ ionophore on mitochondria in intact cells.
Cell
Calcium. 2003 Feb;33(2):101-12. |
| |
Gil-Parrado S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater
F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H,
Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W.
Ionomycin -activated calpain triggers apoptosis. A
probable role for Bcl-2 family members.
J Biol Chem. 2002 Jul
26;277(30):27217-26 |
