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cancer research reagents

Ionomycin (Calcium salt)

MSDSSample CoA
 
Source: Streptomyces conglobatus
Synonyms 
Description: Ionomycin : a  Ca++ ionophore
CAS number: 56092-82-1
Merck index:  
Molecular weight: 747.07
Structure:

ionomycin Calcium salt structure

 

Molecular Formula: C41H70O9Ca
Canonical SMILES:  
Solubility
information:
DMSO, Ethanol, Methanol
Specifications 
Appearance: White to pale yellow crystalline solid.
Purity: At least 98% by TLC, HPLC         current lot : 99.2% by HPLC
λmax: 
Melting point204C-206C
SolubilityClear colorless solution at  5 mg in 1 ml of DMSO
Storage+4C. Protect from light.
Applications Ionomycin is more effectivethan A23187 as a Ca++ionophore.
Ionomycin  is used in research on  Ca
++ transport across biological membranes;
Ionomycin induces apoptotic degeneration of embryonic cortical neurons
WarningsPotentially hazardous.. To our knowledge, the hazards of this material have not yet been thoroughly investigated.
ClassificationFatty acid antibiotic
Calcium Ionophore
Related productsAlso available as free acid
 For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
Publications 
  Holmes AG, Watt MJ, Carey AL, Febbraio MA.
Ionomycin , but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release.
Metabolism. 2004 Nov;53(11):1492-5.
  McCollum AT, Jafarifar F, Chan R, Guttmann RP.
Oxidative stress inhibits ionomycin -mediated cell death in cortical neurons.
J Neurosci Res. 2004 Apr 1;76(1):104-9.
  Cavarra MS, Assef YA, Kotsias BA.
Effects of ionomycin and thapsigargin on ion currents in oocytes of Bufo arenarum.
J Exp Zoolog A Comp Exp Biol. 2003 Jun 1;297(2):130-7.
  Abramov AY, Duchen MR.
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells.
Cell Calcium. 2003 Feb;33(2):101-12.
  Gil-Parrado S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W.
Ionomycin -activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
J Biol Chem. 2002 Jul 26;277(30):27217-26

 

 
 


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