| Source: | Streptomyces Hygroscopicus var Geldanus |
| Synonyms |
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| Description: | Benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters its function. |
| CAS number: | 30562-34-6 |
| Merck index: | |
| Molecular weight: | 560.6 |
| Structure: | 
 |
| Molecular Formula: | C29H40N2O9 |
| Canonical SMILES: |
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)
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Solubility
information: | Geldanamycin is soluble in DMSO, Dichloromethane.
Geldanamycin is insoluble in Water |
| Specifications | |
| Appearance: | Yellow solid. |
| Purity | At least 98% by TLC, HPLC |
| λmax: | (Methanol): 255, 304 |
| Melting point | 265ºC - 268ºC |
| Solubility | Clear yellow solution at 10 mg/ml in Dichloromethane |
| Storage | -20°C. Protect from light. |
| Applications | Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors. |
| Classification | benzoquinone ansamycin antibiotic
geldanamycin derivate
HSP90 inhibitor |
| Warnings | TOXIC |
| Related products | 17-(Allylamino)-17-demethoxy- geldanamycin (17AAG) ; (17-DMAG) 17-dimethylaminoethylamino-17-demethoxy- Geldanamycin |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used.
Raw materials from animal origin info
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| Publications | |
| | Kiang JG, Bowman PD, Wu BW, Hampton N, Kiang AG, Zhao B, Juang YT, Atkins JL, Tsokos GC.
Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in un-resuscitated mouse organs: Role of inducible HSP-70.J Appl Physiol. 2004 Apr 16 |
| | Bedin M, Gaben AM, Saucier C, Mester J.
Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest.
Int J Cancer. 2004 May 1;109(5):643-52. |
| | Li YH, Tao PZ, Liu YZ, Jiang JD.
Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.
Antimicrob Agents Chemother. 2004 Mar;48(3):867-72. |
| | Mandler R, Kobayashi H, Hinson ER, Brechbiel MW, Waldmann TA.
Herceptin- geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer Res. 2004 Feb 15;64(4):1460-7. |
| | Nielsen TO, Andrews HN, Cheang M, Kucab JE, Hsu FD, Ragaz J, Gilks CB, Makretsov N, Bajdik CD, Brookes C, Neckers LM, Evdokimova V, Huntsman DG, Dunn SE.
Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin.
Cancer Res. 2004 Jan 1;64(1):286-91. |
| | Machida H, Matsumoto Y, Shirai M, Kubota N.
Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
Int J Radiat Biol. 2003 Dec;79(12):973-80. |
| | Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D.
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Cancer Res. 2003 Dec 15;63(24):8984-95. |
| | Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D.
Geldanamycin associated inhibition of intracellular trafficking is attributed to a co-purified activity.
J Biol Chem. 2004 Feb 20;279(8):6847-52. Epub 2003 Dec 01. |
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