|Source: ||Coleus forskohlii (plant extract)|
|Description: ||Forskolin is a labdane diterpene that is produced by Coleus forskohlii |
|CAS number: ||66575-29-9|
|Merck index: ||13, 2500|
|Molecular weight: ||410.5 (anhydrous)|
|Molecular Formula: ||C22H34O7 |
|Canonical SMILES: || CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)|
is soluble in DMSO, Methanol, Ethanol, Dichloromethane,
Forskolin may be
dissolved in 2% ethanol in water, by dissolving it first in Ethanol and
subsequently diluting this solution with water.
|Appearance: ||Off-white crystalline solid.|
|Purity: ||At least 97% by TLC, HPLC|
|λmax: ||210, 305|
|Melting point: ||228°C-230°C|
|Solubility: ||Clear colorless solution
at 10mg/ ml EtOAc|
||Room temperature or below. Light protection is recommended by other sources.|
|Applications: ||Forskolin is a vasodilator, hypotensive agent. |
Forskolin activates Adenylate Cyclase, thus increasing the cyclic AMP intra-cellular concentration.
Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology.
Forskolin has been mentioned as a possible weight loss
aid, and as a mean to treat Glaucoma, as it may reduce the intraocular
pressure. See also United States Patent Application 20100168014
||May be irritating on contact with skin |
|Related products|| |
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
raw materials from
animal source were used.
Forskolin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
| ||Asif AR, Ljubojevic M, Sabolic I, Shnitsar V, Metten M, Anzai N, Mueller GA, Burckhardt G, Hagos Y.|
Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEAS treatment in adrenocortical cells.
Am J Physiol Endocrinol Metab. 2006 Jul 11
| ||Curtin BF, Pal N, Gordon RK, Nambiar MP.|
Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression and protects against organophosphate exposure in neuro 2A cells.
Mol Cell Biochem. 2006 Aug 19