| Source: | Fusarium sp |
| Synonyms | Anguidin, Anguidine |
| Description: | Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals. |
| CAS number: | 2270-40-8 |
| Merck index: | Not listed |
| Molecular weight: | 366.4 |
| Structure: | 
 |
| Molecular Formula: |
C19H26O7 |
| Canonical SMILES: |
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Solubility
information: | Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone |
| Specifications | |
| Appearance: | White powder. |
| Purity: | At least 97% by TLC |
| λmax: | |
| Melting point | 160°C- 164°C |
| Solubility | Clear colorless solution at 10 mg / 1 cc methanol
Clear colorless solution at 10 mg / 1 cc dichloromethane |
| Storage | +4°C. |
| Applications | Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement. |
| Warnings | diacetoxyscirpenol is a teratogen |
| Classification | trichothecene mycotoxin
Apoptosis inducer |
| Related products | T2 toxin , Vomitoxin (deoxynivalenol) ,
Diacetoxyscirpenol
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
diacetoxyscirpenol by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Lee DH, Park T, Kim HW.
Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with Diacetoxyscirpenol (Anguidine) mycotoxins.
Biol Pharm Bull. 2006 Apr;29(4):648-54. |
| | Mizuno S.
Mechanism of inhbition of protein systhesis initiation by Diacetoxyscirpenol (Anguidine) and fusarenon X in the reticulocyte lysate system.
Biochim Biophys Acta. 1975 Mar 10;383(2):207-14. |
| | Goodwin W, Haas CD, Fabian C, Heller-Bettinger I, Hoogstraten B.
Phase I evaluation of anguidine (diacetoxyscirpenol, NSC-141537).
Cancer. 1978 Jul;42(1):23-6. |
| | Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C.
Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and Diacetoxyscirpenol (Anguidine) .
Immunology. 1979 Jan;36(1):111-7. |
| | Craddock VM.
Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver.
IARC Sci Publ. 1987;(84):266-9. |
| | Diggs CH, Scoltock MJ, Wiernik PH.
Phase II evaluation of Diacetoxyscirpenol (Anguidine) (NSC-141537) for adenocarcinoma of the colon or rectum.
Cancer Clin Trials. 1978 Winter;1(4):297-9. |
| | Claridge CA, Schmitz H, Bradner WT. Antitumor activity of some microbial and chemical transformation products of anguidine (4,15- diacetoxyscirpeneol).
Cancer Chemother Pharmacol 1979;2(3):181-2. |
