Dactinomycin ( )
Sample CoA
Synonyms: | Actinomycin IV ,
Actinomycin D, Actinomycin C1, Dactinomycin, Cosmegen |
Source: | Streptomyces Parvulus |
Description: | Dactinomycin (Actinomycin D) is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Dactinomycin binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.
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CAS number: | 50-76-0 |
Merck index: | 12, 2867 |
Molecular weight: | 1255.5 |
Structure: |
 |
Molecular Formula: | C62H86N12O16 |
Product Specifications
Appearance: |
Red Shiny Crystals |
Purity: |
At least 98% by TLC. At least 98% by HPLC at 244nm and 441nm |
Solubility: |
Dactinomycin is soluble in Dichloromethane or Methanol .
10 mg/ml of Dactinomycin gives a clear orange solution |
lmax: |
244nm, 441nm |
Melting point: |
245°C-255°C |
Storage: |
+4°C. Protect from light. |
Applications |
Inhibitor of DNA-primed RNA polimerase and DNA polimerase. An apoptosis inducer. Antineoplastic drug |
Caution: |
TOXIC |
Related products
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7Amino-Actinomycin D
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For Research use only. Not for Human or Drug use
Selected reviews concerning the usage of Dactinomycin
Treatment of high-risk gestational trophoblastic neoplasia with etoposide, methotrexate, Dactinomycin, cyclophosphamide, and vincristine chemotherapy.
Clinical studies of Dactinomycin with special reference to Wilms' tumor in children.
Effects of Dactinomycin on fetal growth in rats. |
