| Source: | Aspergillus clavatus |
| Synonyms | |
| Description: | Cytochalasin E is an inhibitor of actin polymerization in blood platelets. Inhibits angiogenesis and tumor growth. Unlike cytochalasins A and B, it does not inhibit glucose transport. |
| CAS number: | 36011-19-5 |
| Merck index: | |
| Molecular weight: | 495.6 |
| Structure: | 
 |
| Molecular Formula: | C28H33NO7 |
| Canonical SMILES: |
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Solubility
information: | DMSO, ethyl acetate, ethanol, dichloromethane |
| Specifications | |
| Appearance: | White powder. |
| Purity: | At least 98% by TLC |
| λmax: | |
| Melting point | 205°C-210°C |
| Solubility | |
| Storage | +4°C. Protect from light. |
| Applications | |
| Warnings | Toxic |
| Classification | Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor |
| Related products | Cytochalasin A, Cytochalasin B, Dihydro-Cytochalasin B, Cytochalasin C, Cytochalasin D, Cytochalasin E |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Cytochalasin E by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Ikewaki N, Yamada A, Inoko H.
Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line.
Microbiol Immunol. 2003;47(10):775-83. |
| | Udagawa T, Yuan J, Panigrahy D, Chang YH, Shah J, D'Amato RJ.
Free Full Text Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth.
J Pharmacol Exp Ther. 2000 Aug;294(2):421-7 |
| | Hansson KM, Tengvall P, Lundstrom I, Ranby M, Lindahl TL.
Comparative studies with surface plasmon resonance and free oscillation rheometry on the inhibition of platelets with cytochalasin E and monoclonal antibodies towards GPIIb/IIIa.
Biosens Bioelectron. 2002 Sep;17(9):761-71. |
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