|Source: ||Zygosporium mansonii|
|Description: ||Cytochalasin D is a cell permeable mycotoxin, which causes both the association and dissociation of actin subunits. Cytochalasin D disrupts actin filaments and inhibits actin polymerization. |
|CAS number: ||22144-77-0|
|Merck index: ||13, 2819|
|Molecular weight: ||507.6|
|Molecular Formula: ||C30H37NO6 |
|DMSO, Ethanol, Methanol|
|Appearance: ||White powder |
|Purity: ||At least 98% by TLC|
|Storage||Store at -20°C. Protect from light. |
|Applications||Cytochalasins are used as tools in cytological research, and in the field of actin polymerisation|
Cytochalasin D is 10 times more effective than cytochalasin B and does not inhibit glucose transport across cell membranes.
May be fatal if inhaled, swallowed/absorbed through skin
May cause irritation. May affect the liver. Possible teratogen.
Possible irreversible effects and teratogen
|Classification||Macrolide indol mycotoxin|
Cytochalasin A, Cytochalasin B, Dihydro-Cytochalasin B, Cytochalasin C, Cytochalasin D, Cytochalasin E
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
Cytochalasin D by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
| ||Salu KJ, Bosmans JM, Huang Y, Hendriks M, Verhoeven M, Levels A, Cooper S, De Scheerder IK, Vrints CJ, Bult H.|
Effects of cytochalasin D -eluting stents on intimal hyperplasia in a porcine coronary artery model.
Cardiovasc Res. 2006 Feb 1;69(2):536-44. Epub 2005 Dec 28.
| ||Loy F, Puxeddu R, Isola M, Loffredo F, Riva A, Testa Riva F.|
Morphological alterations induced by cytochalasin D on serous cells of human submandibular gland in basal and stimulated conditions.
Ital J Anat Embryol. 2005;110(2 Suppl 1):65-70.
| ||Hayduk EJ, Lee KH.|
Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells.
Biotechnol Bioeng. 2005 May 5;90(3):354-64.
| ||Salu KJ, Huang Y, Bosmans JM, Liu X, Li S, Wang L, Verbeken E, Bult H, Vrints CJ, De Scheerder IK.|
Addition of cytochalasin D to a biocompatible oil stent coating inhibits intimal hyperplasia in a porcine coronary model.
Coron Artery Dis. 2003 Dec;14(8):545-55.
| ||Mortensen K, Larsson LI.|
Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis.
Cell Mol Life Sci. 2003 May;60(5):1007-12.
This moderately rapid growing fungus
(mold) produces gray, brown, or black colony in one week, when incubated at 25oC. The hyphae,
conidiophores, and conidia are colored khaki-brown.
Zygosporium masonii is found worldwide on leaves and other
parts of plants, and on decaying plant matter.
has not been reported as of human pathogen.