| Source: | Zygosporium mansonii |
| Synonyms | Zygosporin A |
| Description: | Cytochalasin D is a cell permeable mycotoxin, which causes both the association and dissociation of actin subunits. Cytochalasin D disrupts actin filaments and inhibits actin polymerization. |
| CAS number: | 22144-77-0 |
| Merck index: | 13, 2819 |
| Molecular weight: | 507.6 |
| Structure: | 
 |
| Molecular Formula: | C30H37NO6 |
Solubility
information: | DMSO, Ethanol, Methanol |
| Specifications | |
| Appearance: | White powder |
| Purity: | At least 98% by TLC |
| λmax: | |
| Melting point | 255°C-260°C |
| Solubility | |
| Storage | Store at -20°C. Protect from light. |
| Applications | Cytochalasins are used as tools in cytological research, and in the field of actin polymerisation Cytochalasin D is 10 times more effective than cytochalasin B and does not inhibit glucose transport across cell membranes. |
| Warnings | TOXIC.
May be fatal if inhaled, swallowed/absorbed through skin
May cause irritation. May affect the liver. Possible teratogen.
Highly toxic
Possible irreversible effects and teratogen |
| Classification | Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor |
| Related products | Cytochalasin A, Cytochalasin B, Dihydro-Cytochalasin B, Cytochalasin C, Cytochalasin D, Cytochalasin E |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Cytochalasin D by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Salu KJ, Bosmans JM, Huang Y, Hendriks M, Verhoeven M, Levels A, Cooper S, De Scheerder IK, Vrints CJ, Bult H.
Effects of cytochalasin D -eluting stents on intimal hyperplasia in a porcine coronary artery model.
Cardiovasc Res. 2006 Feb 1;69(2):536-44. Epub 2005 Dec 28. |
| | Loy F, Puxeddu R, Isola M, Loffredo F, Riva A, Testa Riva F.
Morphological alterations induced by cytochalasin D on serous cells of human submandibular gland in basal and stimulated conditions.
Ital J Anat Embryol. 2005;110(2 Suppl 1):65-70. |
| | Hayduk EJ, Lee KH.
Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells.
Biotechnol Bioeng. 2005 May 5;90(3):354-64. |
| | Salu KJ, Huang Y, Bosmans JM, Liu X, Li S, Wang L, Verbeken E, Bult H, Vrints CJ, De Scheerder IK.
Addition of cytochalasin D to a biocompatible oil stent coating inhibits intimal hyperplasia in a porcine coronary model.
Coron Artery Dis. 2003 Dec;14(8):545-55. |
| | Mortensen K, Larsson LI.
Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis.
Cell Mol Life Sci. 2003 May;60(5):1007-12. |
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Zygosporium masonii
This moderately rapid growing fungus
(mold) produces gray, brown, or black colony in one week, when incubated at 25oC. The hyphae,
conidiophores, and conidia are colored khaki-brown.
Zygosporium masonii is found worldwide on leaves and other
parts of plants, and on decaying plant matter.
Zygosporium
masonii
has not been reported as of human pathogen. |
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