|Source: ||Metarhyzium anisopliae|
|Description: ||A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments.|
|CAS number: ||22144-76-9|
|Merck index: ||13, 2819|
|Molecular weight: ||507.6|
|Molecular Formula: ||C30H37NO6|
|Dichloromethane , Ethyl acetate|
|Appearance: ||White solid.|
|Purity: ||At least 97% by TLC|
|Melting point|| |
|Storage||-20°C. Protect from light.|
|Applications||Cytochalasins are used as tools in cytological research, and in the field of actin polymerisation|
|Classification||Macrolide indol mycotoxin|
Cytochalasin A, Cytochalasin B, Dihydro-Cytochalasin B, Cytochalasin C, Cytochalasin D, Cytochalasin E
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
Cytochalasin C by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
|Publications||Patwardhan BH, Flashner M, Miller CA, Tanenbaum SW|
cytochalasin C related compounds: Structure-activity correlations of cytochalasins. Novel halogenated and related and D derivatives
J Med Chem. 1982 Jun;25(6):663-6
cytochalasin C related compounds: A series of halogenated and related analogues of cytochalasin C and cytochalasin D has been synthesized, and the biological activities of the analogues as inhibitors in a cell-free contractility model system obtained from Ehrlich ascites tumor cells were evaluated. The reaction sequence involved treatment of cytochalasin D with phenyltrimethylammonium perbromide to give 6,12-dibromo-cytochalasin D (2), dehydrohalogenation of 2 to 12-bromo-cytochalasin C (3), and the subsequent conversions of 3 to 12-azido- (4), 12-iodo- (5), and 12-cyano-cytochalasin C (6). The ID50 values for 5, 3, 4, 2, and 6 are 6.0, 7.4, 8.8, 45, and 77 X 10(-7) M, respectively, in comparison to ca. 2.8 X 10(-7) M for the parental compounds. The potential cell and molecular biological applications of these compounds are delineated
| ||Noel S, Kasinathan M, Rath SK.|
Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay.
Toxicol In Vitro. 2006 Oct;20(7):1168-72.
| ||J Med Chem. 1982 Jun;25(6):663-6.|
Structure-activity correlations of cytochalasins. Novel halogenated and
related cytochalasin C and cytochalasin D derivatives.
Patwardhan BH, Flashner M, Miller CA, Tanenbaum SW.
A cockroach infected by Metarrhizium anisopliae