| Source: | Metarhyzium anisopliae |
| Synonyms | |
| Description: | A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. |
| CAS number: | 22144-76-9 |
| Merck index: | 13, 2819 |
| Molecular weight: | 507.6 |
| Structure: | 
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| Molecular Formula: | C30H37NO6 |
| Canonical SMILES: |
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Solubility
information: | Dichloromethane , Ethyl acetate |
| Specifications | |
| Appearance: | White solid. |
| Purity: | At least 97% by TLC |
| λmax: | |
| Melting point | |
| Solubility | |
| Storage | -20°C. Protect from light. |
| Applications | Cytochalasins are used as tools in cytological research, and in the field of actin polymerisation |
| Warnings | TOXIC. |
| Classification | Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor |
| Related products | Cytochalasin A, Cytochalasin B, Dihydro-Cytochalasin B, Cytochalasin C, Cytochalasin D, Cytochalasin E |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Cytochalasin C by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | Patwardhan BH, Flashner M, Miller CA, Tanenbaum SW
cytochalasin C related compounds: Structure-activity correlations of cytochalasins. Novel halogenated and related and D derivatives
J Med Chem. 1982 Jun;25(6):663-6cytochalasin C related compounds: A series of halogenated and related analogues of cytochalasin C and cytochalasin D has been synthesized, and the biological activities of the analogues as inhibitors in a cell-free contractility model system obtained from Ehrlich ascites tumor cells were evaluated. The reaction sequence involved treatment of cytochalasin D with phenyltrimethylammonium perbromide to give 6,12-dibromo-cytochalasin D (2), dehydrohalogenation of 2 to 12-bromo-cytochalasin C (3), and the subsequent conversions of 3 to 12-azido- (4), 12-iodo- (5), and 12-cyano-cytochalasin C (6). The ID50 values for 5, 3, 4, 2, and 6 are 6.0, 7.4, 8.8, 45, and 77 X 10(-7) M, respectively, in comparison to ca. 2.8 X 10(-7) M for the parental compounds. The potential cell and molecular biological applications of these compounds are delineated |
| | Noel S, Kasinathan M, Rath SK.
Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay.
Toxicol In Vitro. 2006 Oct;20(7):1168-72. |
| | J Med Chem. 1982 Jun;25(6):663-6.
Structure-activity correlations of cytochalasins. Novel halogenated and
related cytochalasin C and cytochalasin D derivatives.
Patwardhan BH, Flashner M, Miller CA, Tanenbaum SW. |
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 A cockroach infected by Metarrhizium anisopliae |
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