| Source: | Penicillium citrinum |
| Synonyms | EINECS 208-257-2 |
| Description: | Citrinin is a mycotoxin capable of inducing mitochondrial permeability transition. Citrinin also inhibits microtubule polymerization |
| CAS number: | 518-75-2 |
| Merck index: | |
| Molecular weight: | 250.25 |
| Structure: | 
 |
| Molecular Formula: | C13H14O5 |
| Canonical SMILES: |
CC1C(OC=C2C1=C(C(=C(C2=O)C(=O)O)O)C)C |
Solubility
information: |
slightly soluble in water
soluble in dilute alkaline solutions
soluble in methanol, ethanol, acetonitrile |
| Specifications | |
| Appearance: | yellow crystalline solid. |
| Purity: | At least 99% by TLC, HPLC |
| λmax: | |
| Melting point | 173ºC - 174ºC |
| Solubility | Clear yellow solution at 10mg/ml Dichloromethane |
| Storage | -20°C. Protect from light. |
| Applications | Initially isolated as a broad-spectrum antibiotic. |
| Warnings | Warning. Hazardous. Nephrotoxic |
| Classification | Benzopyranmycotoxin
apoptosis inducer |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Citrinin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Chan WH, Shiao NH.
Effect of citrinin on mouse embryonic development in vitro and in vivo.
Reprod Toxicol. 2007 May 10 |
| | Singh ND, Sharma AK, Dwivedi P, Patil RD, Kumar M.
Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study.
J Appl Toxicol. 2007 Apr 11 |
| | Iwahashi H, Kitagawa E, Suzuki Y, Ueda Y, Ishizawa YH, Nobumasa H, Kuboki Y, Hosoda H, Iwahashi Y.
Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray.
BMC Genomics. 2007 Apr 5;8:95 |
| | Fu G, Xu Y, Li Y, Tan W.
Construction of a replacement vector to disrupt pksCT gene for the mycotoxin citrinin biosynthesis in Monascus aurantiacus and maintain food red pigment production.
Asia Pac J Clin Nutr. 2007;16 Suppl 1:137-42. |
| | Chan WH.
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts.
Biochem J. 2007 Jun 1;404(2):317-26. |
