| Source: |
Streptomyces griseus sub griseus |
| Synonyms |
Aburamycin B, Antibiotic 69895 A , Antibiotic B 599 , NSC-58514,
Olivomycin D, 3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabinohexopyranosyl)-7-methyl- ,
Toyomycin |
| Description: |
Chromomycin A3 : glycosidic antibiotic. |
| CAS number: |
7059-24-7 |
| Merck index: |
13, 2258 |
| Molecular weight: |
1183.3 |
| Structure: |
 |
| Molecular Formula: |
C57H82O26 |
Solubility
information: |
DMSO, Ethyl Acetate, Methanol |
| Specifications |
|
| Appearance: |
Yellow powder |
| Purity: |
At least 95% by TLC. At least 93% by HPLC |
| lmax: |
(in methanol ) 229, 277, 316, 331 |
| Melting point | 158°C-163°C |
| Solubility |
|
| Storage |
+4°C. Protect from light. |
| Applications |
Membrane-impermeant G/C-specific fluorescent DNA-binding dye.
Antibacterial antibiotic.
Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors. |
| Warnings |
TOXIC. May be fatal if inhaled or swallowed. Skin permeable. May cause harm to the unborn child. |
| Classification |
Glycosidic antibiotic |
| Related products |
7AAD |
| |
For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications |
Menendez N, Nur-e-Alam M, Fischer C, Brana AF, Salas JA, Rohr J, Mendez C.
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.
Appl Environ Microbiol. 2006 Jan;72(1):167-77. |
| |
Menendez N, Nur-e-Alam M, Brana AF, Rohr J, Salas JA, Mendez C.
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.
Chem Biol. 2004 Jan;11(1):21-32. |
