| Source: |
Chelidonium majus |
| Synonyms |
EINECS 223-444-9
1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium
chloride |
| Description: |
Chelerythrine: A benzophenanthridine alkaloid. A potent, selective, and cell-permeable PKC inhibitor.
Chelerythrine is very closely related to sanguinarine. Unlike
sanguinarine which is found in the green biomass of
Chelidonium, Chelerythrine mainly occurs in its roots. |
| CAS number: |
3895-92-9 |
| Merck index: |
14:2051 |
| Molecular weight: |
383.8 |
| Structure: |
 |
| Molecular Formula: |
C21H18NO4Cl |
| Canonical SMILES: |
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-] |
Solubility
information: |
Methanol, Water, DMSO |
| Specifications |
|
| Appearance: |
Yellow powder.
|
| Purity: |
At least 97% by TLC, HPLC |
| λmax: |
226, 283, 319 |
| Melting point | 200°C-206°C |
| Solubility |
Clear yellowish solution at 5mg/ml methanol |
| Storage |
-20°C. |
| Applications |
|
| Warnings |
HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN IRRITATION |
| Classification |
Benzophenanthridine alkaloid
PKC inhibitor |
| Related products |
|
| |
For Research use only. Not for Human or Drug use
GMP/API grade available on request
 Plant
extract.
Chelerythrine by Fermentek
is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | | | | Vespalec R, Bartak P, Simanek V, Vlckova M.
Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group.
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Nov 25;797(1-2):357-66. |
| |
Bai LP, Zhao ZZ, Cai Z, Jiang ZH.
Site-specific binding of
chelerythrine to single cytosine and thymine bulges in DNA
hairpins.
Nucleic Acids Symp Ser (Oxf). 2006;(50):197-8 |
| |
Kosina P, Walterova D, Ulrichova J, Lichnovsky V, Stiborova M, Rydlova H, Vicar J, Krecman V, Brabec MJ, Simanek V.
Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.
Food Chem Toxicol. 2004 Jan;42(1):85-91. |
| |
Lou H, Ookhtens M, Stolz A, Kaplowitz N.
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells.
Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1335-44 |
| |
Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC.
Identification of chelerythrine as an inhibitor of BclXL function.
J Biol Chem. 2003 Jun 6;278(23):20453-6 | |
|
