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cancer research reagents

Castanospermine

MSDSSample CoA
 
Source: Castanospermum australe (plant extract)
Synonyms 1,6,7,8-Tetrahydroxyoctahydroindolizine
Description: Alkaloid extracted from an australian legume. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Inhibits angiogenesis.
CAS number: 79831-76-8
Merck index: 14: 1896
Molecular weight: 189.2
Structure:

Molecular Formula: C8H15NO4
Canonical SMILES 
Solubility
information:
Soluble in water.
Specifications  
Appearance: White to off-white solid.
Purity: At least 98% by TLC, HPLC
λmax:  
Melting point

212-215 C (decomposition)

Solubility  
Storage +4C or below.
Applications
  • Potent inhibitor of α- and β-glucosidases.

  • Inhibits HIV infectivity.

  • Inhibits angiogenesis

  • Inhibits thyroglobulin secretion

  • Antitumor activty.

  • Inhibits protein glycosylation.

Warnings The pharmacological and toxicological properties of this product have not been fully investigated
Classification indolizidine alkaloid
angiogenesisinhibitor
Related products  
  For Research use only. Not for Human or Drug use
GMP/API grade available on request
Plant extract.
Castanospermine by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used.
Publications Hunter R, Rees-Jones SC, Su H.
Vinylogous Mukaiyama aldol reactions with 4-oxy-2-trimethylsilyloxypyrroles: relevance to castanospermine synthesis
Beilstein J Org Chem. 2007 Nov 3;3:38.
  Durrant C, Moore SE
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine - treated cells.
Biochem J. 2002 Jul 1;365(Pt 1):239-47
  Whitby K, Pierson TC, Geiss B, Lane K, Engle M, Zhou Y, Doms RW, Diamond MS.
Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo.
J Virol. 2005 Jul;79(14):8698-706


castanospermine is extracted from the seeds of castanospermium

The seeds of castanospermium australe

credit and is given to the Australian National Botanic Gardens

 



Castanospermine on AIDSmap


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Mail Address:
Yatziv 25, Atarot industrial zone,
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Fax:     972 2 5853943
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Classification: Natural Products - Alkaloid Signal Transduction Pathway Modulators

Castanospermine by Fermentek for sale.