| Source: |
Castanospermum australe (plant extract) |
| Synonyms |
1,6,7,8-Tetrahydroxyoctahydroindolizine |
| Description: |
Alkaloid extracted from an australian legume. Potent inhibitor of α- and β-glucosidase
activity in fibroblast extracts; inhibits the
glycoprotein processing cycle. Exhibits
antiviral properties. Inhibits angiogenesis. |
| CAS number: |
79831-76-8 |
| Merck index: |
14: 1896 |
| Molecular weight: |
189.2 |
| Structure: |
 |
| Molecular Formula: |
C8H15NO4 |
| Canonical SMILES | |
Solubility
information: |
Soluble in water. |
| Specifications |
|
| Appearance: |
White to off-white solid.
|
| Purity: |
At least 98% by TLC, HPLC |
| λmax: |
|
| Melting point |
212-215
°C
(decomposition) |
| Solubility |
|
| Storage |
+4°C
or below. |
| Applications |
-
Potent
inhibitor of
α- and β-glucosidases.
-
Inhibits HIV infectivity.
-
Inhibits angiogenesis
-
Inhibits thyroglobulin secretion -
Antitumor activty.
-
Inhibits protein glycosylation.
|
| Warnings |
The pharmacological and
toxicological properties of this product have
not been fully investigated |
| Classification |
indolizidine alkaloid
angiogenesisinhibitor |
| Related products |
|
| |
For Research use only. Not for Human or Drug use
GMP/API grade available on request
 Plant
extract.
Castanospermine by Fermentek
is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications |
Hunter R, Rees-Jones SC, Su H.
Vinylogous Mukaiyama aldol reactions with
4-oxy-2-trimethylsilyloxypyrroles: relevance to
castanospermine synthesis
Beilstein J Org Chem. 2007 Nov 3;3:38. |
| |
Durrant C, Moore SE
Perturbation of free oligosaccharide trafficking
in endoplasmic reticulum glucosidase I-deficient
and castanospermine - treated cells.
Biochem J. 2002 Jul 1;365(Pt 1):239-47 |
| |
Whitby K, Pierson TC, Geiss B, Lane K, Engle M,
Zhou Y, Doms RW, Diamond MS.
Castanospermine, a potent inhibitor of dengue
virus infection in vitro and in vivo.
J Virol. 2005 Jul;79(14):8698-706 |
