fermentek makes and sells biochemicals for research
 
Fermentek products delivered worldwide by courier
Fermentek homepage
about
support, sale policy, gmo, mad cow safety, privacy products
contact us
cancer research reagents

Brefeldin A

MSDSSample CoA
 
Source: Eupenicillium brefeldianum
Synonyms Nectrolide
Synergisidin
Cyanaein
Ascotoxin
Cyanein
Decumbin
brefeldin A

Systematic name: (1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one
Description: A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.
CAS number: 20350-15-6
Merck index: 11, 1363
Molecular weight: 280.4
Structure:

 

 

Molecular Formula: C16H24O4
Canonical SMILES: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O 
Solubility
information:
Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate
Specifications
  
Appearance: White to off-white crystalline solid.
Purity: At least 98% by TLC
λmax: 
Melting point198°C-205°C
SolubilityClear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml Methanol.
Storage-20°C
ApplicationsInhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion
WarningsTOXIC
Classificationmacrocyclic lactone antibiotic.
Antifungal
Antiviral
Protein Synthesis Inhibitor
Related products 
 For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
Publications 
 Khine AA, Tam P, Nutikka A, Lingwood CA.
Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity.
Glycobiology. 2004 Apr 21
 Salles FT, Hespanhol AM, Jaeger RG, Marques MM.
Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells.
Oral Oncol. 2004 Jul;40(6):585-90.
 Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M.
Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2752-7.
 Mossessova E, Corpina RA, Goldberg J.
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism.
Mol Cell. 2003 Dec;12(6):1403-11.
 Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M.
Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line.
Pancreas. 2003 Oct;27(3):220-4.
 Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M.
Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin.
Histochem Cell Biol. 2003 Aug;120(2):121-8.
 Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY.
Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.
Int Immunopharmacol. 2003 Jun;3(6):835-43.
 Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL.
Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons.
Neuropharmacology. 2003 Jun;44(8):1107-17.
 Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C.
Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines.
Oncology. 2003;64(4):459-67.
 Edward_B_Neufeld , Adele M. Cooney , Josef Pitha, Eliezar A. Dawidowicz , Nancy K. Dwyer, Peter G. Pentchev, E. Joan Blanchette-Mackie
Brefeldin A applications: Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin
BJU International, Volume 271, Number 35, Issue of August 30, 1996 pp. 21604-21613


Brefeldin A on Wikipedia


fermentek 

Sitemap

Home Hebrew About  us ISO GMP/API Products Mad cow Sales policy Receiving RFQ Ask scientistContact salesPrivacy  About website 

Products

7AAD17AAG17DMAGA23187 ActinomycinAflatoxin B1Aflatoxin B2Aflatoxin M1AlamethicinAnisomycinApicidinAphidicolinAscomycin
Bafilomycin Brefeldin CastanospermineCeruleninChelerythrineChromomycin A3CitreoviridinCitrininCyclopamineCytochalasin ACytochalasin B
Cytochalasin CCytochalasin DCytochalasin EDihidrocytochalasinDeoxynivalenolDiacetoxyscirpenolFK506ForskolinFumagillinFumonisinGeldanamycin
GliotoxinHypericinHT2 toxinIonomycinK252AK252CKT5720KT5823Leptomycin BMithramycin AMoniliforminMycophenolicMyriocinNigericin
NonactinOchratoxin AOligomycinParthenolidePatulinPaxillinePenicillic acidPenitremPKC412PuromycinPuromycin ANRadicicolStaurosporine
SterigmatocystinT2 toxinTentnoxinThapsigarginThiolutinThiostreptonTriacsinTrichostatinTunicamycinValinomycinVerruculogenVomitoxin
Withaferin WortmanninZearalenone

statcounter 

unique visitor counter
 
Company's eMail: 

Anti-spam measures have been taken here. Please copy this address into your eMail software. We are sorry for the inconvenience.

Mail Address:
Yatziv 25, Atarot industrial zone,
POB 47120, Jerusalem 97800 Israel
Fax:     972 2 5853943
Phone: 972 2 5853953

 brefeldin A for sale at Fermentek biochemicals