| Source: | Eupenicillium brefeldianum |
| Synonyms | Ascotoxin, Cyanein, Decumbin |
| Description: | A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity. |
| CAS number: | 20350-15-6 |
| Merck index: | 11, 1363 |
| Molecular weight: | 280.4 |
| Structure: |
 |
| Molecular Formula: | C16H24O4 |
Solubility
information: |
Methanol, Ethanol, Dichloromethane, DMSO, acetone
or ethyl acetate |
| Specifications |
|
| Appearance: | White to off-white crystalline solid. |
| Purity: | At least 98% by TLC |
| λmax: | |
| Melting point | 198°C-205°C |
| Solubility | Clear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml Methanol. |
| Storage | -20°C |
| Applications | Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion |
| Warnings | TOXIC |
| Classification | macrocyclic lactone
antibiotic.
Antifungal
Antiviral
Protein Synthesis Inhibitor |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Khine AA, Tam P, Nutikka A, Lingwood CA.
Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity.
Glycobiology. 2004 Apr 21 |
| | Salles FT, Hespanhol AM, Jaeger RG, Marques MM.
Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells.
Oral Oncol. 2004 Jul;40(6):585-90. |
| | Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M.
Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2752-7. |
| | Mossessova E, Corpina RA, Goldberg J.
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism.
Mol Cell. 2003 Dec;12(6):1403-11. |
| | Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M.
Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line.
Pancreas. 2003 Oct;27(3):220-4. |
| | Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M.
Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin.
Histochem Cell Biol. 2003 Aug;120(2):121-8. |
| | Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY.
Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.
Int Immunopharmacol. 2003 Jun;3(6):835-43. |
| | Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL.
Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons.
Neuropharmacology. 2003 Jun;44(8):1107-17. |
| | Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C.
Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines.
Oncology. 2003;64(4):459-67. |
| | Edward_B_Neufeld , Adele M. Cooney , Josef Pitha, Eliezar A. Dawidowicz , Nancy K. Dwyer, Peter G. Pentchev, E. Joan Blanchette-Mackie
Brefeldin A applications: Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin
BJU International, Volume 271, Number 35, Issue of August 30, 1996 pp. 21604-21613 |
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