| Source: |
Streptomyces griseus |
| Synonyms |
Setamycin |
| Description: |
Bafilomycin B1 is toxic macrolide antibiotic derived from
Streptomyces griseus, that acts as a specific inhibitor of vacuolar-type
H+-ATPase.
|
| CAS number: |
88899-56-3 |
| Merck index: |
not listed |
| Molecular weight: |
816 |
| Structure: |
 |
|
Molecular Formula: |
C44H65NO13 |
|
Solubility information |
Reportedly soluble in ethanol, methanol, DMF or DMSO. Warning: may form
methyl ketal on long term storage in methanol |
| Specifications | |
| Appearance: |
Yellow powder |
| Purity: |
Not less than 95% by HPLC, TLC. |
| λmax: |
255 |
| Melting point |
|
| Solubility |
5mg/ml DMSO , clear yellow solution
5mg/ml
Methanol, clear yellow solution |
| Storage |
LIGHT SENSITIVE; Store at -20°C; |
| Applications |
Bafilomycin B1 is a specific inhibitor of vacuolar type
H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms. Bafilomycin B1 can prevent the re-acidification of synaptic vesicles
once they have undergone exocytosis.
Antibacterial, Antifungal, Antineoplastic, Immunosuppressive
Bafilomycin B1 shares the same mode of action and activity as its
more accessible
Bafilomycin A1
analogue. Bafilomycin B1 is broadly active against bacteria, fungi,
insects, nematodes and protozoans. Bafilomycin B1 has attracted interest
as a potential antiosteoporotic agent in treating bone lytic diseases.
Bafilomycins have been considered as possible therapeutic agents in
the treatment of gastritis. |
|
Related products |
Bafilomycin A1
|
| Classification |
macrolide antibiotic |
| Warnings |
Very Toxic |
| |
For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified
organisms are used. |
| Publications |
|
| |
Inhibition of the accumulation of lipid droplets in macrophage J774 by
bafilomycin B1 and destruxin E
Naganuma S, Kuzuya N, Sakai K, Hasumi K, Endo A.
Biochim Biophys Acta. 1992 Jun 5;1126(1):41-8 |
| |
Setamycin, a new antibiotic.
Omura S, Otoguro K, Nishikiori T, Oiwa R, Iwai Y.
J Antibiot (Tokyo). 1981 Oct;34(10):1253-6. |
| |
Emanuele Papini, Marina de Bernard, Massimo Bugnoli,
Elisabetta Milia, Rino Rappuoli, Cesare Montecucco
Cell vacuolization induced by Helicobacter pylori: Inhibition by
bafilomycins A1, B1, C1 and D
FEMS Microbiology Letters 113 (2) , 155–159 |
|
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