Bafilomycin A1 is
toxic macrolide antibiotic derived from Streptomyces griseus, that acts as a specific inhibitor of vacuolar-type H+-ATPase. |
|Soluble in 100% ethanol,
methanol or DMSO. |
||Not less than 95% by HPLC, TLC. |
|Melting point|| |
||5mg/ml DMSO , clear yellow solution|
5mg/ml Methanol, clear yellow solution
||LIGHT SENSITIVE; Store at -20°C;|
|Applications||Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.|
Bafilomycin A1 is useful in distinguishing among different types of ATPases.
can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Antibacterial, Antifungal, Antineoplastic, Immunosuppressive
has been shown to decrease multi-drug resistance
|Warnings||Toxicological properties of this compound have not been yet fully investigated. |
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
materials of animal origin are used. Mad-cow
safety information on request.
No genetically modified organisms are used.
||New Scientist magazine, 21 June 2003, page 26|
All the female offspring of pregnant mice fed water laced with
Bafilomycin A1, a toxin produced by bacteria that sometimes infect potatoes, developed type 1 diabetes by 30 weeks old. Only 70 per cent of the female offspring of mice in a control group did the same, Mark Myers of Monash University near Melbourne, Australia, told an American Diabetes Association meeting in New Orleans this week. Male offspring were also more susceptible to diabetes if their mothers were fed Bafilomycin, but the effect was less striking. The team has already shown that the toxin damages insulin-producing pancreatic cells of adult mice.
||Covi JA, Hand SC.|
Energizing an Invertebrate Embryo:
Bafilomycin A1-Dependent Respiration and the Metabolic Cost of
Proton Pumping by the V-ATPase.
Physiol Biochem Zool. 2007