| Source: | Streptomyces hygroscopicus
subspascomyceticus |
| Synonyms | Immunomycin, FK520
|
| Description: | A potent immunosuppressant. Inhibits allogenic T-lymphocyte proliferation. An 21-ethyl analog of FK506. |
| CAS number: | 11011-38-4 |
| Merck index: | |
| Molecular weight: | 792.0 |
| Structure: |
 |
| Molecular Formula: | C43H69NO12 |
| Canonical SMILES: |
CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3
C(=O)OC(C(C(CC1=O)O)C)C(=
CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C |
Solubility
information: | DMSO, Methanol, Ethanol |
| Specifications | |
| Appearance: | White crystalline solid. |
| Purity: | At least 90% by TLC, HPLC |
| λmax: | |
| Melting point | 159°C - 164ºC |
| Solubility | Ascomycin gives clear colorless solution at 10mg/ml DMSO |
| Storage | -20°C. Protect from light. |
| Applications | Immunosuppressant. Allogenic T-lymphocyte proliferation inhibitor. Calcineurin phosphatase inhibitor. |
| Warnings | TOXIC. HARMFUL IF SWALLOWED |
| Classification | macrolide
immunosuppressant |
| Related products |
Tacrolimus (FK506)
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Ascomycin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications |
|
| | Vázquez-López A, Sierra-Paredes G, Sierra-Marcuño G.
Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.
Pharmacol Biochem Behav. 2006 Jul;84(3):511-6. Epub 2006 Jul 26. |
| | Monaghan P, Fardis M, Revill WP, Bell A.
Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds.
J Infect Dis. 2005 Apr 15;191(8):1342-9 |
