| Source: | Fusarium sp |
| Synonyms | Apicidin is commonly misspelled as Apidicin |
| Description: | Potent cell permeable inhibitor of histone deacetylase |
| CAS number: | 183506-66-3 |
| Merck index: | |
| Molecular weight: | 623.8 |
| Structure: | 
 |
| Molecular Formula: | C34H49N5O6 |
Solubility
information: | Ethanol, DMSO, Dichloromethane.
Slightly soluble in water, methanol. |
| Specifications | |
| Appearance: | Off-white to white powder. |
| Purity: | At least 98% by TLC, HPLC ; current lot 100% pure |
| λmax: | |
| Melting point | current lot (#APC001): 190oC; (For your information only, not spec) |
| Solubility | Clear colorless solution at 1 mg Apicidin in 1 ml EthOH;
Clear colorless solution at 1 mg Apicidin in 1 ml DMSO; |
| Storage | -20°C. |
| Applications | Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. A histone deacetylase inhibitor, apicidin is anti-angiogenic and induces apoptosis. |
| Warnings | Very toxic by inhalation, in contact with skin and if swallowed |
| Classification | cyclic peptide
antibiotic
Mycotoxin
antiprotozoal
HDAC inhibitor
angiogenesis inhibitor |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Di Renzo F, Broccia M, Giavini E, Menegola E.
Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, sodium butyrate.
Toxicol Sci. 2007 May 21 |
| | Eun DW, Ahn SH, You JS, Park JW, Lee EK, Lee HN, Kang GM, Lee JC, Choi WS, Seo DW, Han JW.
PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.
Biochem Biophys Res Commun. 2007 Mar 16;354(3):769-75 |
