|Source: ||Nigrospora oryzae|
|Description: ||A tetracyclic diterpene antibiotic with antiviral and antimithotical properties. Aphidicolin blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase A, in eukaryotic cells and in some viruses. Apoptose inducer in HeLa cells|
|CAS number: ||38966-21-1|
|Merck index: ||12, 769|
|Molecular weight: ||338.5 |
|Molecular Formula: ||C20H34O4|
|Appearance: ||White to off-white powder|
|Purity: ||At least 97% by TLC|
|Solubility||Clear colorless solution at 50mg/ml of DMSO, 10mg/ml of Methanol |
|Storage||+4°C. Protect from light.|
|Applications||Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.|
Aphidicolin is a tool in cell proliferation and differentiation research. Aphidicolin may possibly be used for controlling excessive cell proliferation in cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
|Warnings||TOXIC. POTENTIAL CARCINOGEN|
DNA polymerase A inhibitor
|Related products|| |
| ||For Research use only. Not for Human or Drug use|
GMP/API grade available on request
No genetically modified organisms are used.
| ||Samake S, Smith LC.|
Synchronization of cell division in eight-cell bovine embryos produced in vitro: Effects of aphidicolin.
Theriogenology. 1997 Oct 15;48(6):969-76.
| ||Kurose A, Tanaka T, Huang X, Traganos F, Dai W, Darzynkiewicz Z.|
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.
Cytometry A. 2006 Apr;69(4):212-21.
Aphidicolin on Wikipedia
J Natl Cancer Inst. 1991 Aug
Phase I and clinical pharmacological evaluation of
Sessa C, Zucchetti M, Davoli E, Califano
R, Cavalli F, Frustaci S, Gumbrell L, Sulkes A, Winograd B,
Servizio Oncologico, Ospedale San Giovanni, Bellinzona,
Treatment of tumor cells in vitro
with neurotrophic factors and cell proliferation
United States Patent
for treating a cultured neuroblastoma cell:
... contacting the neuroblastoma cell with a neurotrophic
factor and a sublethal dose of an inhibitor of cell
proliferation selected from the group consisting of
aphidicolin, hydroxyurea, and
thymidine for about 1 to 15 days...