Anisomycin is a protein synthesis inhibitor. It binds to
subunits and prevents the formation of peptide
bond, and consequently, the chain elongation. |
|Anisomycin is also soluble in DMSO,
Ethyl-Acetate, Dichloromethane. Slightly soluble in
||At least 98% by TLC|
||Clear colorless solution at 10 mg of
Anisomycin in 1 ml of Ethyl Acetate|
||+4°C. Protect from light.|
Originally discovered by Sobin and
Tanner in 1954, Anisomycin was identified as an
antibiotic active against protozoa such as Trichomonas
and fungi and yeasts, and was considered as a potential
human anti-candidal and anti-amoebic drug.
Sobin, B. A., and F. W. Tanner,
Jr. 1954. Anisomycin, a new antiprotozoa antibiotic.
J. Am. Chem. Soc. 76:4053.
As such, Anisomycin was put by GONZALEZ CONSTANDSE
to clinical trials in 1955:
Anisomycin in intestinal
amebiasis; study of 30 clinical cases
Prensa Med Mex. 1956 Sep-Dec;21(7-10):114-5
Anisomycin is also proposed as a potential
psychiatric drug, as it is shown to affect protein
synthesis an Amygdala, a brain part involved in memory(1).
The earliest usage of Anisomycin in research on
memory biochemistry was made by Jonec and
Walsterlain in 1979 . Again, this property of
Anisomycin is ascribed to its ability to inhibit protein
Recently, publications appear showing the
immunomodulating properties on Anisomycin. This
discovery leads to researches on the potential use of
Anisomycin in transplantation:
Effect of inhibitors of protein
synthesis on the development of kindled seizures
Jonec V, Walsterlain CG.
Exp Neurol. 1979 Dec;66(3):524-32
In the field of cell-signaling research,
Anisomycin is used as an activator of kinase cascades in
mammalian cells, especially the stress-activated Protein
Kinase (SAPK2/p38MAPK) and p46/54JNK
Anisomycin inhibits the behaviors of T cells
and the allogeneic skin transplantation in
Xing F et al,
J Immunother. 2008 Nov-Dec;31(9):858-70
Anisomycin is a selective ingredientof Martin Lewis
Agar, a bacteriological solid medium used for isolation
Martin, J. E.,
Jr., and J. S. Lewis. 1977. Anisomycin: improved
antimycotic activity in modified Thayer-Martin
medium. Public Health Lab. 35:53-62
| ||For Research use only. Not
for Human or Drug use|
GMP/API grade available on request
Fermentek is not produced from or contains any ingredients from animal
No genetically modified organisms are used.
Barrientos RM, O'Reilly RC, Rudy JW.|
Anisomycin injection impaired context memory ....
Res. 2002 Aug 21;134(1-2):299-306.
||Freeman FM, Rose SP, Scholey AB.|
Two time windows of anisomycin-induced amnesia for
passive avoidance training in the day-old chick.
Neurobiol Learn Mem. 1995 May;63(3):291-5.
||Butera PC, Campbell RB, Bradway DM.|
Antagonism of estrogenic effects on feeding behavior by
central implants of anisomycin.
Brain Res. 1993
||Staubli U, Faraday R, Lynch G.|
Pharmacological dissociation of memory: anisomycin, a
protein synthesis inhibitor, and leupeptin, a protease
inhibitor, block different learning tasks.
Neural Biol. 1985 May;43(3):287-97.