| Source: | Trichoderma viride |
| Synonyms | Antibiotic U-22324
N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-L-glutamamide
|
| Description: | A peptide antibiotic that can act as a monovalent cation ionophore |
| CAS number: | 27061-78-5 |
| Merck index: | |
| Molecular weight: | 1964.3 |
| Structure: |
Click image to enlarge
 |
| Molecular Formula: | C92H150N22O25 |
| Canonical SMILES |
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Solubility
information: | DMSO, Methanol, Ethanol |
| Specifications | |
| Appearance: | Off white solid |
| Purity: | At least 98% by TLC |
λmax: | Alamethicin shows only end-absorption |
| Melting point | 255°C-270°C |
| Solubility | |
| Storage | -20°C. |
| Applications | Can mimic nerve action potential across artificial membranes |
| Warnings | TOXIC. |
| Classification | Peptide antibiotic
Ionophore |
| Related products | |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
Alamethicin by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Bonnafous JC, Dornand J, Mani JC.
Alamethicin or detergent permeabilization of the cell membrane as a tool for adenylate cyclase determination.
Biochim Biophys Acta. 1982 Jun 8;720(3):235-41. |
| | Vedovato N, Baldini C, Toniolo C, Rispoli G.
Alamethicin : Pore-forming properties F50/5 inserted in a biological membrane.
Chem Biodivers. 2007 Jun;4(6):1338-46. |
| | Woolley GA.
Channel-forming activity of alamethicin: effects of covalent tethering.
Chem Biodivers. 2007 Jun;4(6):1323-37. |
| | Futaki S, Asami K.
Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current.
Chem Biodivers. 2007 Jun;4(6):1313-22. |
| | Stella L, Burattini M, Mazzuca C, Palleschi A, Venanzi M, Coin I, Peggion C, Toniolo C, Pispisa B.
Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues.
Chem Biodivers. 2007 Jun;4(6):1299-312. |
| | Marsh D, Jost M, Peggion C, Toniolo C.
Lipid chain-length dependence for incorporation of alamethicin in membranes: electron paramagnetic resonance studies on TOAC-spin labeled analogs.
Biophys J. 2007 Jun 1;92(11):4002-11. Epub 2007 Mar 9. |
