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cancer research reagents

Aflatoxin M1

MSDSSample CoA
 
Source: Aspergillus flavus
Synonyms4-hydroxyaflatoxin B1
EINECS 229-865-4
Description: Aflatoxin M1 is a  potent hepatotoxic and hepatocarcinogenic mycotoxin, found in milk of cows fed on meal contaminated with Aflatoxin B1
CAS number: 6795-23-9
Merck index: 12, 180
Molecular weight: 328.3
Structure:

Aflatoxin M1 molecular structure

Molecular Formula: C17H1207
Canonical SMILES: COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C(=C1)OC5C4(C=CO5)O
Solubility
information:
Methanol, DMSO
Specifications  
Appearance: Off - white powder. Blue-violet fluorescence
Purity: At least 98% by TLC, HPLC

λmax:

228, 264, 360nm

Melting point  
Solubility  
Storage4°C. Protect from light.
ApplicationsPotent liver carcinogen and DNA-damaging agent.
It is also mutagenic, teratogenic, and causes immunosuppression in animals.
WarningsTOXIC. CARCINOGEN
ClassificationFurano-furano-Benzopyranmycotoxin
Aflatoxin
Related products

Aflatoxin B1 , B2, G1, G2, M1, M2

 For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
Publications  
 Muscarella M, Lo Magro S, Palermo C, Centonze D.
Validation according to European Commission Decision 2002/657/EC of a confirmatory method for aflatoxin M1 in milk based on immunoaffinity columns and high performance liquid chromatography with fluorescence detection.
Anal Chim Acta. 2007 Jul 2;594(2):257-64.
 Boudra H, Barnouin J, Dragacci S, Morgavi DP.
Aflatoxin M1 and ochratoxin A in raw bulk milk from French dairy herds.
J Dairy Sci. 2007 Jul;90(7):3197-201
.
 Tajkarimi M, Shojaee Aliabadi F, Salah Nejad M, Pursoltani H, Motallebi AA, Mahdavi H.
Seasonal study of aflatoxin M1 contamination in milk in five regions in Iran.
Int J Food Microbiol. 2007 May 30;116(3):346-9. Epub 2007 Mar 1.
 Polychronaki N, West RM, Turner PC, Amra H, Abdel-Wahhab M, Mykkanen H, El-Nezami H.
A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers.
Food Chem Toxicol. 2007 Jul;45(7):1210-5.
 Zinedine A, Gonzalez-Osnaya L, Soriano JM, Molto JC, Idrissi L, Manes J.
Presence of aflatoxin M1 in pasteurized milk from Morocco.
Int J Food Microbiol. 2007 Feb 28;114(1):25-9.
AVAILABLE
Standard solutions

 Aflatoxin M1 solution



Asoergillus flavus on PDA agar. This mold pruduces aflatoxin.
Aspergillus flavus culture on agar plate

INCHEM

Aflatoxin M1 review
 

...The European Community supports the maximum level of 0.05 μg/kg for aflatoxin M1 in liquid milk...

...there is sufficient evidence that aflatoxin M1 is a genotoxic carcinogen; its carcinogenic potency is estimated to be approximately 10 times lower than aflatoxin B1...

CODEX COMMITTEE ON FOOD ADDITIVES AND CONTAMINANTS 20-24 March 2000



Aflatoxin on Wikipedia


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