| Source: | Streptomyces Chartreusensis |
| Synonyms | Calcimycin, Calcium Ionophore A23187 |
| Description: | A mobile ion-carrier that forms stable complexes with divalent cations. |
| CAS number: | Not yet assigned. CAS# for the free acid form is 52665-69-7 |
| Merck index: |
12, 1678 |
| Molecular weight: | 523.6 (in solution) |
| Structure: | 
 |
| Molecular Formula: | (C29H36N3O6)2Mg , (C29H36N3O6)2Ca |
Solubility
information: | Dichloromethane, Ethyl acetate. Insoluble in water, pentane, hexane. |
| Specifications | |
| Appearance: | White to off-white crystalline solid |
| Purity | At least 98% by TLC |
λmax: | (in methanol) 227, 302, 371 nm |
| Melting point | |
| Solubility | Clear colorless solution at 10mg/ml of Dichloromethane |
| Storage | +4°C. Protect from light. |
| Applications | Used in cell activation experiments when calcium dose-response data are not required |
| Warnings | |
| Classification | polyether antibiotic
calcium ioniphore |
| Related products | A23187FA (A23187 free acid) A23187CAMG (A23187 mixed Calcium / Magnesium salt) A23187BR (4-Bromo A23187)
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
A23187 by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Chakraborti S, Michael JR, Chakraborti T.
Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A(2) by calcium ionophore (A23187) in pulmonary endothelium.
Cell Signal. 2004 Jun;16(6):751-62 |
