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Source: | Semisynthetic.
Prepared from
A23187 |
| Synonyms | 4-Bromo-A23187,
4-Bromocalcimycin,
4-Bromo-antibiotic A23187,
Systematic Name
4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-(((2S,3S,6S,8S,9R,11R)-3,9,11-trimethyl-8-((1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-
|
| Description: | Brominated Analog of
A23187.
A23187 is an ionophore antibiotic that forms dimeric complexes
with divalent cations such an Mn2+ and Ca2+. |
| CAS number: |
76455-48-6 |
| Merck index: | |
| Molecular weight: | 602.5 |
| Structure: | 
 |
| Molecular Formula: | C29H36BrN3O6 |
| Canonical SMILES: |
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(C(=C(C=C5O4)Br)NC) |
Solubility
information: | DMSO,
Methanol, Dichloromethane |
| Specifications | |
| Appearance: | White crystalline solid. |
| Purity: | At least 98% by TLC, HPLC |
λmax: | |
| Melting point | |
| Solubility | Clear colorless solution at 10
mg/ml of Dichloromethane. |
| Storage | 4°C. Protect from
light and moisture. Stable for 3 years. |
| Applications | Nonfluorescent calcium ionophore used as a calibration
standard for determining cytoplasmic calcium ions by fluorescent probes. |
| Warnings | |
| Classification | polyether antibiotic
calcium ionophore |
| Related products |
A23187FA (A23187 free acid)
A23187CAMG (A23187 mixed Calcium / Magnesium salt)
A23187BR (4-Bromo A23187)
|
| | For Research use only. Not
for Human or Drug use
GMP/API grade available on request
A23187BR by
Fermentek is not produced from or contains any ingredients from animal
origin.
No genetically modified organisms are used. |
| Publications |
|
| | J Dermatol Sci. 2006
Jul;43(1):21-33
ATP2C1 is specifically localized in the basal
layer of normal epidermis and its depletion triggers keratinocyte
differentiation.
Yoshida M, Yamasaki K, Daiho T, Iizuka H, Suzuki
H.
...knockdown
of ATP2C1 induced these differentiation markers of cultured
keratinocytes. Furthermore, treatment of keratinocytes with a
calcium ionophore, A23187, did not up-regulate differentiation
markers of keratinocytes, while a more manganese selective
ionophore Br-A23187 up-regulated these differentiation markers.. |
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DISAMBIGUATION:
one source uses the CAS number [76455-48-6] for
14-Methyl-14H-dibenzo[a,j]xanthene
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