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cancer research reagents

Thiostrepton

MSDSSample CoA
 
Source: Streptomyces sp.
SynonymsAlaninamide,
Bryamycin ,
Thiactin
EINECS 215-734-9
Description: Thiostrepton is a Polypeptide, sulfur containing antibiotic.
CAS number: 1393-48-2
Merck index: 14: 9364
Molecular weight: 1664.89
Structure:

The molecular structure of Thiostrepton. Free to copy

 

Molecular Formula: C72H85N19O18S5
Canonical SMILES: CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)
C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O
)NC(=C)C(=O)N)C)C
Solubility
information:
Thiostrepton issoluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. May be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected  from light.
Specifications
  
Appearance: White to off-white powder
Purity: Single stain by TLC.
At least 97% by HPLC.
λmax: No clear UV maxima but shows shoulders at 225, 250, 280 nm
Melting point: Thiostrepton decomposes at 246-256oC
Solubility: 
Storage:-18oC
Applications: Thiostrepton is used as a reagent for both positive and negative selection of genes involved in nucleotide metabolism.

Thiostrepton  is highly active against gram-positive bacteria.

In its crude form, Thiostrepton is used in veterinary medicine, in mastitis caused by gram-negative organisms and in dermatologic disorders.

Related products: 
Classification: Polypeptide antibiotic
Antimicrobial
Warnings: 
 For Research use only. Not for Human use
GMP/API grade available on request

Animal Free productThiostrepton by Fermentek is not produced from or contains any ingredients from animal origin.

No genetically modified organisms are used.
Publications 
 Gonzalez RL Jr, Chu S, Puglisi JD
NA. 2007 Dec;13(12):2091-7.
Thiostrepton inhibition of tRNA delivery to the ribosome.
 García-Marcos A, Morreale A, Guarinos E, Briones E, Remacha M, Ortiz AR, Ballesta JP.
Nucleic Acids Res. 2007;35(21):7109-17.
In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton.
 Jonker HR, Ilin S, Grimm SK, Wöhnert J, Schwalbe H.
Nucleic Acids Res. 2007;35(2):441-54
L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy.
  


Thiostrepton on Wikipedia


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