| Source: |
Lechevalieria aerocolonigenes |
| Synonyms |
IUPAC name:
1,11-dichloro-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione |
| Description: | Rebeccamycin
: weak topoisomerase I inhibitor
from an actinomycetal source. |
| CAS number: | 93908-02-2 |
| Merck index: | |
| Molecular weight: |
570.4 |
| Structure: |
Rebeccamycin
 |
| Molecular Formula: |
C27H21Cl2N3O7 |
Solubility
information: |
Soluble in DMSO, (at least 3 mg/ml,
Bailly, C, et al., Mol. Pharmacol., 53, 77-87 (1998).
Soluble in THF; moderate solubility in Acetone,
methanol |
| Specifications | |
| Appearance: |
Bright yellow powder |
| Purity: |
|
| λmax: |
|
| Melting point |
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| Solubility |
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| Storage |
-20°C. Protect from light ! |
| Applications |
Rebeccamycin acts as topoisomerase I
inhibitor in a mode
ressembling camptothecines, i.e., by
stabilizing the topoisomerase-DNA covalent complex
so that DNA could
be cleaved but not resealed Because Rebeccamycin is
practically insoluble in water, it was used as a starting
material for the synthesis of many semisynthetic derivates, some
of which reached the step of clinical researches.
|
| Classification |
Antibiotic, Aminoglycoside,
Carbazole Antibiotic |
| Related products |
|
| Warnings | |
| |
For Research use only. Not
for Human or Drug use
GMP/API grade available on request
 Rebeccamycin by Fermentek is not produced from or contains any ingredients from
animal origin.
No genetically modified organisms are used. |
| Publications | |
| |
|
|
|
|
Rebeccamycin on Wikipedia
|
| Clinical perspectives Phase I Clinical and
Pharmacokinetic Study of NSC 655649, a Rebeccamycin
Analogue, Given in Both Single-Dose and Multiple-Dose
Formats
Clin Cancer Res. 2002 Jul;8(7):2193-201.
Merchant J, Tutsch K, Dresen A, Arzoomanian R, Alberti D,
Feierabend C, Binger K, Marnoccha R, Thomas J, Cleary J,
Wilding G.
University of Wisconsin |
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