| | Section 1. Product and Company Information |
| Name: | Neosolaniol |
| CAS Number: | 36519-25-2 Attention: also listed under CAS number 65041-92-1 |
| Catalog Code: | |
| Synonyms | 8-Hydroxydiacetoxyscirpenol Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate |
| Company Identification | Fermentek ltd, See page footer for contact details |
| | Section 2. Composition/Information on Ingredient |
| EINECS/ELINCS | Not listed |
| Chemical Formula: | C19H26O8 |
| Chemical Class: | Trichocene toxin |
| RTECS | YD0080000 |
| TSCA | |
| | Section 3. Hazards Identification |
| EMERGENCY OVERVIEW | - Highly Toxic (USA) Very Toxic (EU).
- Highly toxic by inhalation, in contact with skin and if swallowed.
- Irritating to eyes and skin.
Potential Health Effects - Inhalation May be fatal if inhaled. May cause respiratory tract irritation.
- Skin May cause skin irritation. May be fatal if absorbed through skin.
- Eyes May cause eye irritation.
- Ingestion May be fatal if swallowed.
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| HMIS RATING | - HEALTH: 3
- FLAMMABILITY: 0
- REACTIVITY: 0
|
| NFPARATING | - HEALTH: 3
- FLAMMABILITY: 0
- REACTIVITY: 0
|
| | Section 4. First Aid Measures |
| Eye Contact | Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately. |
| Skin Contact | Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately |
| Inhalation | Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible. |
| Ingestion | Remove dentures and clear mouth. If person is conscious, rinse mouth with water Call physician or poison control immediately. Provide chemical label and MSDS information if possible. |
| | Section 5. Fire and Explosion Data |
| Flammability | Not Available |
| Flash Point | Not Available |
| Combustion products | CO, CO2 |
| Extinguishing Media | Carbon Dioxide, Dry chemical powder, polymer foam, water spray |
Special Firefighting Procedures | Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual Fire/Explosion Hazards | None known |
| | Section 6 - Accidental Release Measures |
| Cleanup Procedures | Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed |
Waste Disposal Method | Observe all Federal, State and Local regulations concerning the disposal of this product.Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete |
| | Section 7 - Handling and Storage |
| Protective Equipment | For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended. |
| Storage and Handling | This product should be kept in a tightly closed container. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18oC |
| | Section 8 - Exposure Controls / Personal protection |
| General | Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low |
| Personal protective equipment | - Respiratory:Government approved respirator.
- Hand:Compatible chemical-resistant gloves.
- Eye:Chemical safety goggles.
|
| | Section 9. Physical Data |
| Appearance | Slight yellow powder |
| Molecular Weight | 382.4 |
| Melting | 176 - 178ºC |
| Solubility | Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone |
| | Section 10. Stability and Reactivity Data |
| Stability | This material is stable if stored as directed |
| Conditions to Avoid | Excess heat, incompatible materials, strong oxidizers |
| Incompatibles | Reactive with oxidizing agents, acids, alkalis. |
| Hazardous polymerization | Will not occur |
| | Section 11 - Toxicological Information |
| RTECS#: | YD0080000 |
| Route of exposure | - Skin Contact: skin irritation.
- Skin Absorption: May be fatal if absorbed through skin.
- Eye Contact: Causes severe eye irritation.
- Inhalation: Material may be irritating to mucous membranes andupper respiratory tract. May be fatal if inhaled.
- Ingestion: May be fatal if swallowed.
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| TARGET ORGAN(S) OR SYSTEM(S) | - Thymus
- Bone marrow
- Spleen
- Blood
- Nerves
|
| Signs and sympromps of exposure | - Nausea
- headache
- Vomiting
- Chills
- Vertigo
- Visual disturbances.
|
| Toxity |
| Organism | Route | LD50 | Effect | Source |
| Chicken | Oral | 24.87 mg/kg | Gastrointest.: hypermotility, diarrhea behav.: muscle weakness; food intake | Applied and environ. Microbial. Vol. 35, pg. 636, 1978. |
| Mouse | Intra-perit. | 14.5 mg/kg | | Jap. journal of experim. med. Vol. 42, pg. 187, 1972. |
| Mouse | Sub-cut. | 9.7 mg/kg | | Toxicon. Vol. 24, pg. 985, 1986. | |
| Chronic exposure | There is inadequate evidence for carcinogenicity in humans. Not classifiable as carcinogene (Source: IARC, OSHA) |
| | Section 12 - Ecological Data |
| Ecotoxicological Information: | None Available |
| | Section 13 - Disposal Considerations |
| Appropriate method of disposal of substance or preparation | Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. |
| | Section 14 - Transport Information |
| US DOT | - UN-Number: 2811 Class: 6.1 Packing group: I
- Proper shipping name: Toxic solids, organic, n.o.s. (Neosolaniol)
- Marine pollutant: No
- Poison Inhalation Hazard: No
|
| IATA | - UN-Number: 2811 Class: 6.1 Packing group: I
- Proper shipping name: Toxic solid, organic n.o.s. (Neosolaniol)
|
| | Section 15-Regulatory Information |
| US classification and label text | OSHA Hazards Highly toxic by inhalation, Highly toxic by ingestion, Highly toxic by skin absorption |
| United states regulatory information Sara listed | SARA 302 Components SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components SARA 313: This material does not contain any chemical components with known CAS numbers that exceed thethreshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazard Acute Health Hazard |
| Eu additional classification | - Symbol of danger: T
- Indication of danger: toxic.
Risk statements - R: 25 toxic if swallowed.
Safety statements - S: 36/37/39-45 : wear suitable protective clothing, gloves, and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
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| | Section 16 -Other Information |
| Disclaimer | For R&D use only. Not for drug, household or other uses |
| Warranty | DISCLAIMER For R&D use only. Not for drug, household or other uses. For use only by trained personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user. Fermentek shall not be held liable or any damage resulting from handling or from contact with the above product.
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