| | Section 1. Product and Company Information |
| Name: | Fumonisin B1 |
| CAS Number: | 116355-83-0 |
| Catalog Code: | |
| Company Identification | Fermentek ltd, See page footer for contact details |
| | Section 2. Composition/Information on Ingredient |
| EINECS/ELINCS | Not listed |
| Chemical Formula: | C34-H59-N-O15 |
| Chemical Class: | |
| RTECS | TZ8350000 |
| TSCA | Not listed |
| | Section 3. Hazards Identification |
| Overview | |
| Hazzard | Cancer suspect agent. |
| Potential accute Health Effects | Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation |
| Potential chronic Health Effects |
- CARCINOGENIC EFFECTS: (Not classifiable for human.) by IARC.
- MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells
- Repeated or prolonged exposure is not known to aggravate medical condition.
|
| | Section 4. First Aid Measures |
| Eye Contact | Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately. |
| Skin Contact | Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately |
| Inhalation | Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible. |
| Ingestion | Remove dentures and clear mouth. If person is conscious, rinse mouth with water Call physician or poison control immediately. Provide chemical label and MSDS information if possible. |
| | Section 5. Fire and Explosion Data |
| Flammability | Not Available |
| Flash Point | Not Available |
| Combustion products | CO, CO2, NO,NO2, |
| Extinguishing Media | Carbon Dioxide, Dry chemical powder, polymer foam, water spray |
Special Firefighting Procedures | Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual Fire/Explosion Hazards | None known |
| | Section 6 - Accidental Release Measures |
| Cleanup Procedures | Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed |
Waste Disposal Method | Observe all Federal, State and Local regulations concerning the disposal of this product. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete |
| | Section 7 - Handling and Storage |
| Protective Equipment | For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended. |
| Storage and Handling | This product should be kept in a tightly closed container. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18oC |
| | |
| | Section 8 - Exposure Controls / Personal protection |
| General | Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low |
| Personal protective equipment |
- Respiratory: Government approved respirator.
- Hand: Compatible chemical-resistant gloves.
- Eye:Chemical safety goggles.
|
| | Section 9. Physical Data |
| Appearance | Solid. (Powdered solid.) |
| Molecular Weight | 721.8 |
| Solubility | Soluble in cold water, methanol, and in acetonitrile |
| | Section10. Stability and Reactivity Data |
| Stability | This material is stable if stored as directed |
| Conditions to Avoid | Excess heat, incompatible materials, strong oxidizers |
| Incompatibles | Not Available |
| Hazardous polymerization | Will not occur |
| | Section11 - Toxicological Information |
| RTECS#: | TZ8350000 |
| Acute toxicity: | none known |
| Route of exposure | Inhalation: Material is irritating to mucous membranes and upper respiratory tract |
| Multiple routes | Harmful if swallowed, inhaled, or absorbed through skin. Causes eye and skin irritation |
| Chronic Effects on Humans | 3 (Not classifiable for human.) by IARC |
| Other Toxic Effects on Humans: | Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation |
| Special Remarks on Toxicity to Animals | May affect liver and kidneys in domestic animals. |
| |
| Citation fromHazardous Substances Data Bank Human Health Effects: Evidence for Carcinogenicity: Evaluation: There is inadequate evidence in humans for the carcinogenicity of toxins derived from Fusarium moniliforme. There is sufficient evidence in experimental animals for the carcinogenicity of cultures of Fusarium moniliforme that contain significant amounts of fumonisins. There is limited evidence in experimental animals for the carcinogenicity of fumonisin B1. Overall evaluation: Toxins derived from Fusarium moniliforme are possibly carcinogenic to humans (Group 2B). /Toxins derived from Fusarium moniliforme/ [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V56 462 (1993)]**PEER REVIEWED** | |
| Special Remarks on Chronic Effects on Humans | May affect genetic material (mutagen). May cause adverse reproductive effects (maternal effects, effects on fertility (post-implantation mortality, fetotoxicity)),and birth defects. |
| Special Remarks on other Toxic Effects on Humans: | - Skin: May cause skin irritation.
- Eyes: Dust may cause eye irritation.
- Inhalation: Dust may cause respiratory tract irritation. Ingestion: May cause gastrointestinal tract irritation.
- Acute or chronic (repeated or prolonged) ingestion may also affect the cardiovascular system, urinary system, liver, blood, metabolism, behavior
|
| | Section12 - Ecological Data |
| Ecotoxicological Information: | None Available |
| Products of Biodegradation | Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. |
| Toxicity of the Products of Biodegradation | The product itself and its products of degradation are not toxic |
| | Section13 - Disposal Considerations |
| Appropriate method of disposal of substance or preparation | Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. |
| | Section14 - Transport Information |
| Non-Hazardous for transport | This substance is considered to be non-hazardous for transport |
| US DOT | Not regulated |
| | Section15 - regulatory Information |
| TSCA | Not listed on the TSCA inventory. It is for research and development use only. |
| WHMIS (Canada) | Not controlled under WHMIS (Canada). |
| DSCL (EEC): | R40- Possible risks of irreversible effects. S2- Keep out of the reach of children. S36/37- Wear suitable protective clothing and gloves |
| HMIS (U.S.A.) | Health Hazard: 1 Fire Hazard: 1 Reactivity: 0 Personal Protection: E |
| | Section16 - Other Information |
| Disclaimer | For R&D use only. Not for drug, household or other uses |
| Warranty | DISCLAIMER For R&D use only. Not for drug, household or other uses. For use only by trained personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user. Fermentek shall not be held liable or any damage resulting from handling or from contact with the above product. |
