| | Section 1. Product and Company Information |
| Name: | Wortmannin |
| CAS Number: | 19545-26-7 |
| Catalog Code: | Wortmannin |
| Company Identification | Fermentek ltd, See page footer for contact details |
| | Section 2. Composition/Information on Ingredient |
| EINECS/ELINCS | not listed |
| Chemical Formula: | C23H24O8 |
| Chemical Class: | Androstadiene |
| RTECS |
CB9641000 |
| TSCA | Not
On TSCA Inventory |
| | Section 3. Hazards Identification |
| Acute Health Effects | To the best of our knowledge, the toxicological properties of this compound have not been fully investigated. Exercise appropriate precautions to prevent opportunities for inhalation, and to prevent direct contact with skin and eyes. All uncharacterized chemicals should be treated as suspected toxins. |
| Emergency overview |
Danger!
MAY BE FATAL IF ABSORBED THROUGH SKIN OR IF SWALLOWED.
Do not ingest. Do not get in eyes or on skin or clothing. Wash thoroughly
after handling |
| OSHA/HCS status |
This material is considered hazardous by the OSHA Hazard
Communication Standard(29 CFR 1910.1200). |
| Target organ |
Heart |
| Eye | May cause eye irritation |
| Skin: | Very toxic if absorbed through the skin |
| Ingestion: | Very
toxic if swallowed |
| Inhalation: | Very
toxic if inhaled |
| Chronic Health Effects | unknown |
| NFPA Rating |
-
Health Hazard: 4
-
Fire : 0
-
Reactivity Hazard: 0
|
| HMIS Classification |
-
Health Hazard 4,
-
Chronic Health Hazard *,
-
Flammability Hazard 0,
-
Physical Hazards 0
|
| | |
| | |
| | Section 4. First Aid Measures |
| Eye Contact | Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately. |
| Skin Contact | Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately |
| Inhalation | Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible. |
| Ingestion |
-
Remove dentures and clear mouth.
-
Only If Conscious, rinse mouth with water,
give water to drink.
-
Only If Conscious,
induce vomiting by pushing fingers down the throat.
-
Call physician or poison control immediately. Provide chemical label and MSDS information if possible.
-
Urgent hospitalization is likely to be needed.
|
| | Section 5. Fire and Explosion Data |
| Flammability | Not Available |
| Flash Point | Not Available |
| Combustion Products | CO, CO2, |
| Extinguishing Media | Carbon Dioxide, Dry chemical powder, polymer foam, water spray |
| Special Firefighting Procedures | Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual Fire/Explosion Hazards | None known |
| | Section 6 - Accidental Release Measures |
| Cleanup Procedures | Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed |
| Waste Disposal Method | Observe all Federal, State and Local regulations concerning the disposal of this product. |
| | Section 7 - Handling and Storage |
| Protective Equipment | For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended. |
| Storage and Handling | This product should be kept in a tightly closed container. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material.
Store at -18oC. |
| | Section 8 - Exposure Controls / Personal protection |
| General | Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low |
| Personal protective equipment | -
Respiratory: Government approved respirator. -
Hand: Compatible chemical-resistant gloves. -
Eye: Chemical safety goggles.
-
Other protection
-
for dealing with amounts below 1/2 Kg, a common
laboratory gown may be sufficient.
|
| | Section 9. Physical Data |
| Appearance | White Powder |
| Molecular Weight | 428.1632 |
| Solubility | DMSO, Ethanol |
| | Section 10. Stability and Reactivity Data |
| Stability | This material is stable if stored as directed |
| Conditions to Avoid | Excess heat, incompatible materials, strong oxidizers |
| Incompatibles | Not Available |
| Hazardous polymerization | Will not occur |
| | Section 11 - Toxicological Information |
| RTECS#: |
CB9641000 |
| Acute toxicity: | none known |
| Signs and Symptoms of Exposure |
-
Gastric hemorrhage
-
Myocardial hemorrhage.
|
| Carcinogenicity | Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA |
| LD50 |
Organism
Route |
LD50 |
Source |
Mouse
intra peritoneal | 18mg/kg |
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca
Raton, FL, CRC Press, 1980Vol. 6, Pg. 168, 1981. |
|
| | Section 12 - Ecological Data |
| Ecotoxicological Information: |
Wortmannin: do not discharge into sewage. |
| | Section 13 - Disposal Considerations |
| Appropriate method of disposal of substance or preparation |
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. |
| | Section 14 - Transport Information |
| IATA | UN-Number: 3462 Class: 6.1 Packing
group: II
Proper shipping name: Toxins, extracted from living sources, solid n.o.s.
(Wortmannin) |
| IMDG | UN-Number: 3462 Class: 6.1 Packing
group: II EMS-No: F-A, S-A
Proper shipping name: Toxins, extracted from living sources, solid n.o.s.
(Wortmannin)
Marine pollutant: No |
| US DOT |
 UN-Number: 3462 Class: 6.1
Packing group: II
Proper shipping name: Toxins, extracted from living sources, solid, n.o.s.
(Wortmannin) |
| | Section 15 -
Regulatory Information |
| TSCA |
Not on TSCA inventory |
| OSHA Hazards |
Delayed target organ effects, Highly toxic
by inhalation, Highly toxic by ingestion, Highly toxic by skin
absorption |
| SARA |
not listed |
| Clean Water Act |
not listed |
| Clean Air Act |
not listed |
| Risk phrases |
- R26/27/28: Very toxic by inhalation, in contact with skin and if
swallowed
|
| Safety phrases |
-
S22- Do not breathe dust.
-
S36/37/39- Wear suitable protective clothing, gloves
and eye/face protection.
-
S45- In case of accident or if you feel unwell, seek
medical advice immediately (show the label
where possible).
|
| | Section 16 - Other Information |
| Disclaimer | For R&D use only. Not for drug, household or other uses |
| Warranty | DISCLAIMER For R&D use only. Not for drug, household or other uses. For use only by trained personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user. Fermentek shall not be held liable or any damage resulting from handling or from contact with the above product. |
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- updated:
2-june-2010
- updated 21-june-2010 packing group II based
on toxicity
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