| | Section 1. Product and Company Information |
| Name: | Colchicine |
| CAS Number: |
64-86-8
|
| Catalog Code: | |
| Synonyms |
|
| Company Identification | Fermentek ltd, See page footer for contact details |
| | Section 2. Composition/Information on Ingredient |
| EINECS/ELINCS |
EC# 200-598-5 |
| Chemical Formula: | |
| Chemical Class: | |
| RTECS | GH0700000 |
| TSCA | |
| | Section 3. Hazards Identification |
| Emergency overview |
Routes
- Skin contact.
- Eye contact
- Ingestion.
- Inhalation
Target Organs
- Pancreas
- Liver
- Kidney
- Blood
- Reproductive system.
|
| | |
| | |
| Potential Health Effects |
Potential Acute Health Effects:
Extremely hazardous in case of skin contact (corrosive, irritant, sensitizer,
permeator), of eye contact (irritant), of ingestion, of inhalation. The amount
of tissue damage depends on length of contact. Eye contact can result in corneal
damage or blindness. Skin contact can produce inflammation and blistering.
Inhalation of dust will produce irritation to gastro-intestinal or
respiratory tract, characterized by burning, sneezing and coughing.
Severe over-exposure can produce lung damage, choking, unconsciousness or death.
Inflammation of the eye is characterized by redness, watering, and itching. Skin
inflammation is characterized by itching, scaling, reddening, or, occasionally,
blistering. Potential Chronic Health Effects:
Extremely hazardous in case of skin contact (corrosive, irritant, sensitizer,
permeator), of eye contact (irritant), of ingestion, of
inhalation.
Carcinogenic effects: Not available.
Mutagenic effects: Not available.
Teratogenic effects: Not available.
Developmental toxicity: PROVEN
The substance is toxic to blood, kidneys, lungs, the nervous system, the
reproductive system, liver, mucous membranes. Repeated or prolonged exposure to
the substance can produce target organs damage. Repeated exposure of the eyes to
a low level of dust can produce eye irritation. Repeated skin exposure can
produce local skin destruction, or dermatitis. Repeated inhalation of dust can
produce varying degree of respiratory irritation or lung damage. Repeated
exposure to an highly toxic material may produce general deterioration of health
by an accumulation in one or many human organs. Repeated or prolonged inhalation
of dust may lead to chronic respiratory irritation. |
| HMIS rating | - HEALTH: 4
-
FLAMMABILITY: 1
- REACTIVITY: 0
|
| NFPA rating | - HEALTH: 4
-
FLAMMABILITY: 1
- REACTIVITY: 0
|
| | Section 4. First Aid Measures |
| Eye Contact | Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately. |
| Skin Contact | Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately.
|
| Inhalation | Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible. |
| Ingestion | Remove dentures and clear mouth. If person is conscious, rinse mouth with water Call physician or poison control immediately. Provide chemical label and MSDS information if possible. |
| | Section 5. Fire and Explosion Data |
| Flammability |
|
| Flash Point | Not Available |
| Combustion Products | CO, CO2, NO,NO2, |
| Extinguishing Media | Carbon Dioxide, Dry chemical powder, polymer foam, water spray |
| Special Firefighting Procedures | Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual Fire/Explosion Hazards | None known |
| | Section 6 - Accidental Release Measures |
| Cleanup Procedures | Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed |
| Waste Disposal Method | Observe all Federal, State and Local regulations concerning the disposal of this product. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete |
| | Section 7 - Handling and Storage |
| Protective Equipment | For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended. |
| Storage and Handling | It should be kept
in a tightly closed container. This product should be handled only by qualified
experienced professionals. Wash thoroughly after handling this material. Store protected from light and moisture. |
| | Section 8 - Exposure Controls / Personal protection |
| General | Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low |
| Personal protective equipment | - Respiratory: Government approved respirator.
- Hand: Compatible chemical-resistant gloves.
- Eye:
Chemical safety goggles.
|
| | Section 9. Physical Data |
| Appearance | light yellow crystalline powder. |
| Molecular Weight | 265.2 |
| Melting | 146°C |
| Solubility | soluble in water |
| | Section 10. Stability and Reactivity Data |
| Stability | This material is stable if stored as directed |
| Conditions to Avoid | Excess heat, incompatible materials, strong oxidizers |
| Incompatibles | Reactive with oxidizing agents, acids, alkalis. |
| Hazardous polymerization | Will not occur |
| | Section 11 - Toxicological Information |
| RTECS#: | GH0700000 |
| Route of exposure |
- Inhalation: May be fatal if inhaled. Causes respiratory tract
irritation.
- Ingestion: May be fatal if swallowed.
- Skin: May be harmful if absorbed through skin. Causes skin irritation.
May be fatal if absorbed through skin.
- Eyes: causes eye irritation.
|
| Target systems | |
| Symptoms |
Vomiting, Diarrhoea.
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated |
| Carcinogenicity |
No positive data available |
| Developmental toxicity |
DEVELOPMENTAL TOXICITY: PROVEN The substance is toxic to blood,
kidneys, lungs, the nervous system, the reproductive system, liver, mucous
membranes.
|
| Toxity data |
Organism
Route |
LD50
mg/kg
|
Information source |
|
cat
I-Ven
|
0.25
|
Journal of Pharmacology and Experimental Therapeutics.
Vol. 106, Pg. 261, 1952.
|
|
mouse oral
|
5.9
|
National Cancer Institute Screening Program Data
Summary, Developmental Therapeutics Program. Vol. JAN1986
|
|
| | Section 12 - Ecological Data |
| Ecotoxicological Information: | None Available |
| | Section 13 - Disposal Considerations |
| Appropriate method of disposal of substance or preparation | Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. |
| | Section 14 - Transport Information |
| US DOT |
DOT Classification: CLASS 6.1: Poisonous material.
Identification: : Alkaloid, solid, n.o.s. (Colchicine) : UN1544 PG: II
Small quantities provision applies. |
| IATA class |
UN-Number: 1544 Class: 6.1 Packing group: II
Proper shipping name: Alkaloids, solid, n.o.s. (Colchicine)
|
| | Section 15-Regulatory Information |
| US classification | OSHA Hazards
Target Organ Effect, Highly toxic by inhalation, Highly toxic by ingestion,
Irritant, Teratogen
DSL Status
This product is on the Canadian DSL list.
SARA 302 Components: Colchicine
CAS-No. 64-86-8
SARA 311/312 Hazards: Acute Health Hazard, Chronic Health Hazard
California Prop. 65 Components: WARNING! This product contains a chemical known
to the State of California to cause birth defects or other reproductive harm.
Colchicine
|
| TSCA |
TSCA 8(b)inventory: Colchicine
|
| |
|
| |
Hazard statements
H300 + H330 Fatal if swallowed or if inhaled.
H318 Causes serious eye damage.
Precautionary statements
P260 Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash hands thoroughly after handling.
P280 Wear protective gloves/eye protection/face protection.
P284 Wear respiratory protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
|
| | Section 16 -Other Information |
| Warranty | DISCLAIMER For R&D and manufacturing use only. Not for drug, household or other uses. For use only by trained personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user.
FERMENTEK shall not be held liable or any damage resulting from handling or from contact with the above product.
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