| | Section 1. Product and Company Information |
| Name: | Actinomycin D |
| CAS Number: | 50-76-0 |
| Catalog Code: | DAC |
| Company Identification | Fermentek ltd, See page footer for contact details |
| | Section 2. Composition/Information on Ingredient |
| EINECS/ELINCS | |
| Chemical Formula: | C62H86N12O16 |
| Chemical Class: | |
| RTECS | AU1575000 |
| TSCA | |
| | Section 3. Hazards Identification |
| EMERGENCY OVERVIEW | - Highly Toxic (USA) Very Toxic (EU).
- Very toxic if swallowed.
- Limited evidence of a carcinogenic effect
- May cause sensitization by inhalation and skin contact.
- Possible Carcinogen (US).
- Target organ(s): Bone marrow. Liver.
- Calif. Prop. 65 carcinogen & reproductive hazard
|
| HMIS RATING | HEALTH: 3, FLAMMABILITY: 0, REACTIVITY:0 |
| | Section 4. First Aid Measures |
| Eye Contact | Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately. |
| Skin Contact | Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately |
| Inhalation | Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately. Provide chemical label and MSDS if possible. |
| Ingestion | Remove dentures and clear mouth. If person is conscious, rinse mouth with water Call physician or poison control immediately. Provide chemical label and MSDS information if possible. |
| | Section 5. Fire and Explosion Data |
| Flammability | Not Available |
| Flash Point | Not Available |
| Combustion Products | CO, CO2, NO,NO2, |
| Extinguishing Media | Carbon Dioxide, Dry chemical powder, polymer foam, water spray |
Special Firefighting Procedures | Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. |
| Unusual Fire/Explosion Hazards | None known |
| | Section 6 - Accidental Release Measures |
| Cleanup Procedures | Wearing appropriate protective gear as outlined under “Protective equipment” wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed |
Waste Disposal Method | Observe all Federal, State and Local regulations concerning the disposal of this product.Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete |
| | Section 7 - Handling and Storage |
| Protective Equipment | For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is recommended. |
| Storage and Handling | This product should be kept in a tightly closed container. This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18oC |
| | Section 8 - Exposure Controls / Personal protection |
| General | Use only in a chemical fume hood. Safety shower and eye bath. Use adequate ventilation to keep airborne concentrations low |
| Personal protective equipment | - Respiratory:Government approved respirator.
- Hand:Compatible chemical-resistant gloves.
- Eye:Chemical safety goggles.
|
| | Section 9. Physical Data |
| Appearance | Red Shiny Crystals |
| Molecular Weight | 1,255.5 |
| Solubility | Dichloromethane or Methanol |
| | Section 10. Stability and Reactivity Data |
| Stability | This material is stable if stored as directed |
| Conditions to Avoid | Excess heat, incompatible materials, strong oxidizers |
| Incompatibles | Reactive with oxidizing agents, acids, alkalis. |
| Hazardous polymerization | Will not occur |
| | Section 11 - Toxicological Information |
| RTECS#: | AU1575000 |
| Route of exposure | - Skin Contact: May cause skin irritation.
- Skin Absorption: May be harmful if absorbed through the skin.
- Eye Contact: May cause eye irritation.
- Inhalation: May be harmful if inhaled. Material may be
- irritating to mucous membranes and upper respiratory tract.
- Ingestion: May be fatal if swallowed.
|
| Sensitization | : May cause allergic reaction. |
| TARGET ORGANS | Bone marrow. Liver. Kidneys. |
| Signs and sympromps of exposure | Inhalation may result in spasm, inflammation and edema of the larynxand bronchi, chemical pneumonitis, and pulmonary edema. Exposure can cause: Anemia. Drowsiness. Weakness |
| TOXICITY DATA (LD50) |
| route | orga-nizm | LD50 | Remarks |
| Oral | Rat | 7.2 mg/kg | Gastrointestinal:Hypermotility, diarrhea |
| Intrape-ritoneal | Rat | 100 UG/KG | |
| Intrape-ritoneal | Mouse | 50 UG/KG | Decreased immune response | |
| CHRONIC EXPOSURE – CARCINOGEN | This product has been reported to be possibly carcinogenic based on its IARC, ACGIH, NTP, or EPA classification. Species: Rat ; Route of Application: Intraperitoneal: Dose: 2600 UG/KG Exposure Time: 17W Frequency: I Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic:Tumors at site or application. Species: Mouse Route of Application: Subcutaneous Dose: 280 UG/KG Exposure Time: 18W Frequency: I Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Tumorigenic:Tumors at site or application. |
| CHRONIC EXPOSURE – TERATOGEN | Species: Rat; Dose: 70 NG/KG; Route of Application: Intraperitoneal; Exposure Time: (8D PREG); Result: Specific Developmental Abnormalities: Musculoskeletal system. Species: Rat; Dose: 200 UG/KG; Route of Application: Subcutaneous; Exposure Time: (12D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Effects on Embryo or Fetus: Fetal death. |
| CHRONIC EXPOSURE - MUTAGEN | Species: Human Dose: 400 UG/L Exposure Time: 15M; Cell Type: HeLa cell; Mutation test: DNA damage |
| | Section 12 - Ecological Data |
| Ecotoxicological Information: | None Available |
| | Section 13 - Disposal Considerations |
| Appropriate method of disposal of substance or preparation | Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. |
| | Section 14 - Transport Information |
| US DOT | Proper Shipping Name: Toxic solids, organic, n.o.s.; UN#: 2811; Class: 6.1; Packing Group: Packing Group II; Hazard Label: Toxic substances.; PIH: Not PIH |
| IATA | Proper Shipping Name: Toxic solid, organic, n.o.s.; IATA UN Number: 2811; Hazard Class: 6.1; Packing Group: II |
| | Section 15-Regulatory Information |
| US CLASSIFICATION AND LABEL TEXT | Indication of Danger: Highly Toxic (USA) Very Toxic (EU). Risk Statements: Very toxic if swallowed. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact. Safety Statements: Do not breathe dust. After contact with skin, wash immediately with plenty of soap-suds. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). US Statements: Possible Carcinogen (US). Target organ(s): Bone, marrow. Liver. Calif. Prop. 65 carcinogen & reproductive hazard. |
| UNITED STATES REGULATORY INFORMATION | SARA LISTED: No |
| CALIFORNIA PROP - 65 | California Prop - 65: This product is or contains chemical(s) known to the state of California to cause cancer. This product is or contains chemical(s) known to the state of California to cause developmental toxicity. |
| EU ADDITIONAL CLASSIFICATION | Symbol of Danger: T+ Indication of Danger: Very toxic |
| Risk Statements | R: 28 40 42/43 : Very toxic if swallowed. Limited evidence of acarcinogenic effect. May cause sensitization by inhalation and skin contact |
| Safety Statements | S: 22 28 36/37 45: Do not breathe dust. After contact with skin, wash immediately with plenty of soap-suds. Wear suitableprotective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| | Section 16 -Other Information |
| Disclaimer | For R&D use only. Not for drug, household or other uses |
| Warranty | DISCLAIMER For R&D use only. Not for drug, household or other uses. For use only by trained personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. The burden of safe use of this material rests entirely with the user. Fermentek shall not be held liable or any damage resulting from handling or from contact with the above product.
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