| Source: |
Aspergillus terreus |
| Synonyms | Mevinolin
6-α-Methylcompactin
|
| Description: | Lovastatin is a
strong inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. That
enzyme controls biosynthesis of Cholesterol in liver. Also inhibits MAP
kinase and p21ras activation |
| CAS number: |
75330-75-5 |
| Merck index: |
|
| Molecular weight: | 404.5 |
| Structure: |
 |
| Molecular Formula: | C24H36O5 |
Solubility
information: |
Chloroform - up to 35%
w/v
acetone up to 4% w/v,
acetonitrile up to 3% w/v
Slightly soluble in water (less than 0.5% w/v) |
| Specifications | |
| Appearance: |
Off-white powder. |
| Purity: | At least 98% by TLC. At least
98% by HPLC |
| λmax: | 231, 238,
247 nm |
| Melting point | 169oC-172oC |
| Solubility | MeOH/CH2Cl2 clear colorless
solution at 10mg/ml |
| Storage | +4°C. |
| Applications |
Lovastatin has been reported
to cause cell cycle arrest
Lovastatin was reported to induce apoptosis in several lines
of cancer cells.
arrest
|
| Warnings |
Not considered toxic.
...Overdose of up to 5 to 6 g was tolerated with no specific
symptoms ... (from Toxnet) |
| Classification | Statin
antibiotic
Apoptosis inducer |
| Related products | |
| | For Research use only. Not
for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | |
| | |
| | |
