| Source: |
Semisynthetic, from K252A
from Nocardiopsis sp. |
| Synonyms | |
| Description: | KT5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) |
| CAS number: | 126643-37-6 |
| Merck index: | 14: Not
listed |
| Molecular weight: | 495.5 |
| Structure: | 
 |
| Molecular Formula: | C29H25N3O5 |
| Canonical SMILES: |
|
Solubility
information: | DMSO,
Ethyl Acetate |
| Specifications | |
| Appearance: | White solid |
| Purity: | At least 97% by TLC, HPLC |
| λmax: | |
| Melting point | White powder |
| Solubility | Clear colorless solution at
5mg/ml Ethyl acetate |
| Storage | +4°C. Protect from light. |
| Applications | KT5823 induces apoptotic fragmentation of DNA |
| Warnings | |
| Classification | indolocarbazole alkaloid
PKG inhibitor |
| Related products |
KT5853 , KT5720 , staurosporine , PKC412
K252a , K252B K252c
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
KT5823 by Fermentek is produced
chemically from K252A,
look there forinformation concerning ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Chan SL, Fiscus RR.
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Mol Hum Reprod. 2003 Dec;9(12):775-83. |
| | Miyoshi K, Kawakami N, Horio S, Fukui H.
Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor.
Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):343-7. |
| | Burkhardt M, Glazova M, Gambaryan S, Vollkommer T, Butt E, Bader B, Heermeier K, Lincoln TM, Walter U, Palmetshofer A.
KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
J Biol Chem. 2000 Oct 27;275(43):33536-41. |
| | Wyatt TA, Pryzwansky KB, Lincoln TM.
KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin.
Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14. |
