| Source: |
Semisynthetic. |
| Synonyms |
Staurosporine
aglycone; Staurosporinone |
| Description: |
K252c: Cell permeable protein kinase inhibitor
of the Staurosporine family (indolo[2,3-a]carbazole
alkaloids) |
| CAS number: |
85753-43-1 |
| Merck index: |
Not listed |
| Molecular weight: |
311.3 |
| Structure: |
 |
| Molecular Formula: |
C20H13N3O |
Solubility
information: |
Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;
soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;
Insoluble in water, 2-propanol |
| Specifications |
|
| Appearance: |
Off-white powder |
| Purity: |
At least 97% by TLC |
| λmax: |
|
| Melting point |
|
| Solubility |
Clear colorless solution at 5mg/ml of Dichloromethane |
| Storage |
-20oC. Protect from light. Hygroscopic. Protect from moisture |
| Applications |
K252c inhibits
protein kinase C. Its reported IC50
value of 214 nM on rat brain
enzyme (1)
K252c is cytotoxic for A549
and P388
cancer celllines showing IC 50
= 2-3
mM
|
| Classification |
indolocarbazole alkaloid
PKC inhibitor |
| Warnings |
|
| Related products |
KT5853 , KT5720 , staurosporine , PKC412
K252a , K252B K252c
|
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
K252c by Fermentek is
produced with ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| |
Fabre S, Prudhomme M, Rapp M.
Protein kinase C inhibitors;
structure-activity relationships in K252c-related compounds.
Bioorg Med Chem. 1993 Sep;1(3):193-6 |
| |
(1)Nakanishi S,
Matsuda Y, Iwahashi K, Kase H.
K252b, K252c and K252d,
potent inhibitors of protein kinase C from microbial origin.
"The Journal of antibiotics." - J Antibiot (Tokyo).1986
Aug;39(8):1066-71
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This product will be available soon
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Disambiguation
Do not confuse K252C with a very closely related compound, arcyriaflavin A (CAS
118458-54-1) which is also (erroneously)
called staurosporine aglycon. |
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