|
Source: | Plant extract from
Colchicum autumnale
|
| Synonyms |
Systematic name (USP): Acetamide,
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,
(S)-
EINECS: 200-598-5
RTECS: GH0700000
|
| Description: |
Natural alkloid extracted from the Meadow saffron plant,
Colchicum autumnale
|
| CAS number: | 64-86-8 |
| Merck index: |
14:2471 |
| Molecular weight: | 399.4 |
| Structure: |
 |
| Molecular Formula: |
C22H25NO6
|
Solubility
information: | 50 mg/ml
Ethanol (warm)
freely dissolves in CHCl3
slightly dissolves in Petrol Ether
25 mg/ml water
25 mg/ml DMSO |
| Specifications | |
| Appearance: |
White to slightly yellow powder. |
| Purity: |
Single spot on TLC |
| λmax: | 243 nm, 350 nm |
| Melting point: |
140oC-152oC with decomposition |
| Solubility: |
|
| Storage: |
Protect from moistute.
Protect from light.
May be stored at room temperature; refrigeration preferred.
Solutions are stabile for several weeks when deep frozen. |
| Applications: |
An antimitotic agent that disrupts microtubles by binding to
tubulin and preventing its polymerization. Stimulates the
intrinsic GTPase activity of tubulin. Induces apoptosis in
several normal and tumor cell lines and activates the JNK/SAPK
signal
|
| Related products: | |
| Classification: | Alkaloid
Apoptosis inducer
Tubulin Modulator
Antimitotic Agent
Mitosis Modulator |
| Warnings: |
 T+
Very Toxic.
R46 : May cause heritable genetic damage.
R28 : Very toxic if swallowed.
Colchicine is classified as super toxic. Probable oral lethal
dose in humans is less than 5 mg/kg, i.e. 1/3 gram for a 70 kg
person. Death results from respiratory arrest. |
| | For Research use only. Not for Human or Drug use
 No
raw materials from
animal source were used
Colchicine by Fermentek is not produced from or contains any ingredients from animal origin.
No genetically modified organisms are used. |
| Publications | |
| | Ghatak C, Rao VG, Pramanik R,
Sarkar S, Sarkar N.
Nanocavity Effect On Photophysical Properties Of Colchicine: A Proof
by Circular
Dichroism Study and Picosecond Time-Resolved Analysis in Various Reverse
Micellar Assemblies
J Phys Chem B. 2011 May 4. |
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