| Source: | Semisynthetic. Derived from Actinomycin D (from Streptomyces parvulus) |
| Synonyms |
7AAD, 7-AminoActinomycin D
|
| Description: | 7AADis a semisynthetic derivate of Actinomycin D. 7aad binds to single stranded DNA. |
| CAS number: | 7240-37-1 |
| Merck index: | 13, 2828 |
| Molecular weight: | 1270.4 |
| Structure: | 
 |
| Molecular Formula: | C62H87N13O16 |
| Canonical SMILES: |
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Solubility
information: | Dichloromethane, DMSO, Methanol. Slightly soluble in water |
| Specifications | |
| Appearance: | Purple powder |
| Purity: | At least 96% by TLC, HPLC |
λmax: | |
| Melting point | 245°C-254°C |
| Solubility | 10 mg/ml of methanol gives a clear red solution |
| Storage | -20°C. Protect from light. Hygroscopic! |
| Applications | (7aad) 7-amino-Actinomycin D is an inhibitor of DNA-primed RNA polymerase and DNA polimerase.
7aad (7-amino-Actinomycin D) induces apoptosis.
7aad is used as a fluorescent DNA Stain. Useful tool in determining apoptosis |
| Classification | oligopeptide antibiotic
RNA polymerase inhibitor |
| Related products |
Actinomycin D
|
| Warnings | TOXIC. CARCINOGENIC |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
7-amino-actinomycin D by Fermentek produced
chemically, from Actinomycin_D.
Look there for raw material information
No genetically modified organisms are used. |
| Publications | |
| | Lecoeur H, Ledru E, Prevost MC, Gougeon ML.
Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD ( cytofluorometric staining methods.
J Immunol Methods. 1997 Dec 1;209(2):111-23. |
| | Toba K, Koike T, Watanabe K, Fuse I, Takahashi M, Hashimoto S, Takahashi H, Abe T, Yano T, Shibazaki Y, Itoh H, Aizawa Y.
Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD (7aad) 7-amino-Actinomycin D /PY.
Eur J Haematol. 2000 Jan;64(1):10-21. |
