| Source: | A semisynthetic derivate of
Geldanamycin |
| Synonyms | 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, 17-DMAG
Alvespimycin |
| Description: | 17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. |
| CAS number: | 467214-20-6 |
| Merck index: | |
| Molecular weight: | 616.8 |
| Structure: | 
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| Molecular Formula: | C32H48N4O8 |
| Canonical SMILES: |
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Solubility
information: | DMSO, Methanol, Ethanol |
| Specifications | |
| Appearance: | Purple powder |
| Purity | At least 98% by TLC |
| λmax: | |
| Melting point | |
| Solubility | DMSO, Methanol, Ethanol
Clear purple solution at 10mg 17DMAG in 1 ml of Methanol
Clear purple solution at 25mg 17DMAG in 1 ml of DMSO |
| Storage | -20°C. Protect from light. |
| Applications | Same as Geldanamycin. 17DMAG is less hepato-toxic than Geldanamycin. 17DMAG has cytotoxic activity against many cancer cell lines. 17DMAG is also an angiogenesis inhibitor. |
| Classification | benzoquinone ansamycin antibiotic
geldanamycin derivate
HSP90 inhibitor |
| Related products |
Geldanamycin 17AAG
|
| Warnings | TOXIC |
| | For Research use only. Not for Human or Drug use
GMP/API grade available on request
No genetically modified organisms are used. |
| Publications | |
| | Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM.
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37. Epub 2005 Apr 20. |
| | Eiseman JL, Lan J, Lagattuta TF, Hamburger DR, Joseph E, Covey JM, Egorin MJ.
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts.
Cancer Chemother Pharmacol. 2005 Jan;55(1):21-32. Epub 2004 Aug 27 |
| | Musser SM, Egorin MJ, Zuhowski EG, Hamburger DR, Parise RA, Covey JM, White KD, Eiseman JL.
Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507, 17dmag) and metabolites by Fischer 344 rats.
Cancer Chemother Pharmacol. 2003 Aug;52(2):139-46. Epub 2003 May 22. |
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